Heterotopic Ossification: A Comprehensive Review
Autor: | Jeffrey Lisiecki, Aaron W. James, Benjamin Levi, Laura M. Fayad, Catherine Ding, Edward F. McCarthy, Sarah Miller, Carolyn A. Meyers, Takashi Sono, Adam S. Levin |
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Rok vydání: | 2018 |
Předmět: |
030222 orthopedics
0303 health sciences business.industry Endocrinology Diabetes and Metabolism Soft tissue Heterotopic bone Review Myositis ossificans Tissue repair medicine.disease Bioinformatics HETEROTOPIC BONE Ectopic bone formation FIBRODYSPLASIA OSSIFICANS PROGRESSIVA 3. Good health 03 medical and health sciences 0302 clinical medicine Fibrodysplasia ossificans progressiva medicine MYOSITIS OSSIFICANS Orthopedics and Sports Medicine Heterotopic ossification business ECTOPIC BONE 030304 developmental biology |
Zdroj: | JBMR Plus |
ISSN: | 2473-4039 |
Popis: | Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms. First, the clinical features, radiographic appearance, histopathologic diagnosis, and current methods of treatment are discussed. Next, current concepts regarding the mechanistic bases for HO are discussed, including the putative cell types responsible for HO formation, the inflammatory milieu and other prerequisite “niche” factors for HO initiation and propagation, and currently available animal models for the study of HO of this common and potentially devastating condition. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research. |
Databáze: | OpenAIRE |
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