Metabolic effects of proglycosyn
| Autor: | Heidi L. Behforouz, Kiwami Chikada, Peter Scislowski, Kunio Yamanouchi, Thomas W. Stephens, Robert A. Harris, Samuel J. Dominianni, Anna A. DePaoli-Roach, David W. Allmann |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Atropine
Male medicine.medical_specialty Biophysics 8-Bromo Cyclic Adenosine Monophosphate Phosphoprotein phosphatase activity Biochemistry chemistry.chemical_compound Glycogen phosphorylase Internal medicine Cyclic AMP Phosphoprotein Phosphatases medicine Glycogen branching enzyme Animals Hypoglycemic Agents Phosphorylase a Glycolysis Glycogen synthase Molecular Biology Cells Cultured Fatty acid synthesis biology Imidazoles Rats Inbred Strains Fructose Metabolism Glucagon Liver Glycogen Rats Kinetics Glycogen Synthase Endocrinology Liver Verapamil chemistry biology.protein |
| Zdroj: | Archives of Biochemistry and Biophysics. 294:609-615 |
| ISSN: | 0003-9861 |
| Popis: | Proglycosyn, a phenylacyl imidazolium compound that lowers blood glucose levels, was demonstrated previously to promote hepatic glycogen synthesis, stabilize hepatic glycogen stores, activate glycogen synthase, inactivate glycogen phosphorylase, and inhibit glycolysis. In the present study proglycosyn was found to inhibit fatty acid synthesis, stimulate fatty acid oxidation, and lower fructose 2,6-bisphosphate levels, but to have no significant effects on cell swelling and the levels of cAMP in hepatocytes prepared from fed rats. Verapamil and atropine blocked the effects of proglycosyn on glycogen metabolism, but these compounds inhibit proglycosyn accumulation by hepatocytes. Proglycosyn stimulated phosphoprotein phosphatase activity in postmitochondrial extracts, as measured by dephosphorylation of phosphorylase a and glycogen synthase D, but this action required a very high concentration of the compound, making it unlikely to be the actual mechanism involved. It is proposed that a metabolite of proglycosyn is responsible for its metabolic effects. |
| Databáze: | OpenAIRE |
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