Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production
| Autor: | Dorner, M, Brandt, S, Tinguely, M, Zucol, F, Bourquin, J P, Zauner, L, Berger, C, Bernasconi, M, Speck, R F, Nadal, D |
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| Přispěvatelé: | University of Zurich, Nadal, D |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
2403 Immunology
B-Lymphocytes Plasma Cells Toll-Like Receptors Immunoglobulins 610 Medicine & health Cell Differentiation Original Articles Hematopoietic Stem Cells 10234 Clinic for Infectious Diseases Gene Expression Regulation Immunoglobulin M 10049 Institute of Pathology and Molecular Pathology Immunoglobulin G 2723 Immunology and Allergy Humans RNA Messenger Immunologic Memory Cells Cultured |
| Popis: | Toll-like receptors (TLRs) are key receptors of the innate immune system and show cell subset-specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells from peripheral blood. HSC and plasma cells showed unrestricted expression of TLR1-TLR9, in contrast to B cells which lacked TLR3, TLR4 and TLR8 but expressed mRNA of all other TLRs. We demonstrated, for the first time, that TLR triggering of terminally differentiated plasma cells augments immunoglobulin production. Thus, boosting the immediate antibody response by plasma cells upon pathogen recognition may point to a novel role of TLRs. |
| Databáze: | OpenAIRE |
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