Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor
| Autor: | Yasuo Shikinami, Hitoshi Hirata, Atsumasa Uchida, Kaoru Tsuta, Ko Kato, Aki Fukuda, Kenshi Okazaki, Akihiro Sudo, Masahiro Hasegawa |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cartilage
Articular Materials science Compressive Strength Basic fibroblast growth factor Biophysics Biocompatible Materials Bioengineering Fibroblast growth factor Collagen Type I Biomaterials chemistry.chemical_compound Hardness Materials Testing medicine Animals Drug Implants Cartilage formation Cartilage Articular surface Combined Modality Therapy Bone ingrowth Treatment Outcome medicine.anatomical_structure chemistry Subchondral bone Mechanics of Materials Ceramics and Composites Female Fibroblast Growth Factor 2 Artificial Organs Rabbits Femoral Fractures Type I collagen Biomedical engineering |
| Zdroj: | Biomaterials. 26:4301-4308 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2004.11.007 |
| Popis: | The purpose of this study was to examine the efficacy of a combination of artificial cartilage and basic fibroblast growth factor (bFGF) for the repair of large osteochondral defects. The artificial cartilage was a three-dimensional fabric (3-DF) composed of an ultra-high molecular weight polyethylene fiber with a triaxial three-dimensional structure. We implanted 3-DF impregnated with type I collagen gel containing 500 ng of bFGF (bFGF-treated group) or 3-DF impregnated with type I collagen gel alone (non-treated group) into a large full-thickness osteochondral defect (6×6×3 mm) of the patellar groove of rabbits. The defect area was examined grossly, histologically and biomechanically 4–48 weeks after surgery. Bone ingrowth into and around the 3-DF was evaluated with micro-computed tomography (μ-CT). Addition of bFGF to the 3-DF greatly accelerated cartilage formation on the articular surface and subchondral bone formation into and around the 3-DF, and improved biomechanical properties. These findings suggest that a combination of artificial cartilage and bFGF is clinically useful in cases involving large osteochondral defects. |
| Databáze: | OpenAIRE |
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