Inter-subject variability in the metabolism of aluminium following intravenous injection as citrate
| Autor: | J.G. Austin, D. Newton, R J Talbot, N.D. Priest, J.P. Day |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Daily intake Health Toxicology and Mutagenesis Physiology Urine Toxicology Citric Acid 03 medical and health sciences Feces 0302 clinical medicine Internal medicine Subject variability medicine Toxicokinetics Humans Citrates 030102 biochemistry & molecular biology Chemistry General Medicine Metabolism Light metal Endocrinology 030220 oncology & carcinogenesis Toxicity Injections Intravenous Faecal excretion Aluminum |
| Zdroj: | Humanexperimental toxicology. 14(7) |
| ISSN: | 0960-3271 |
| Popis: | 1 Six healthy male volunteers received intravenous injec tions of 26Al as citrate. Accelerator mass spectrometry and γ-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2 There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and major loss in urine (59% up to 1 d), but 27 ± 7 (s.d.)% was retained in the body at 5 d. Faecal excretion was negligible (1% up to 5 d). 3 The mean results accord with the early metabolic pat tern in the single subject of a previous, more extensive study, who had retained 4% of the injection after 3 y. Together, the two studies point to the likelihood of large inter-subject differences in the long-term accumulation of dietary aluminium by populations receiving a given level of daily intake. |
| Databáze: | OpenAIRE |
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