Ovarian teratoma in a woodchuck (Marmota monax) with hepatocellular carcinoma: radiologic and pathologic features
| Autor: | Matthew F. Starost, Andrew S. Mikhail, Michal Mauda-Havakuk, William F. Pritchard, Ari Partanen, John W. Karanian, Bradford J. Wood, Johnathan Zeng |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology Carcinoma Hepatocellular endocrine system diseases 040301 veterinary sciences Case Report 0403 veterinary science 03 medical and health sciences medicine Animals Hepatitis B Virus Woodchuck Ovarian Teratoma Ultrasonography 030304 developmental biology Ovarian Neoplasms 0303 health sciences Germ cell neoplasm General Veterinary biology business.industry Liver Neoplasms Woodchuck hepatitis virus Teratoma Echogenicity 04 agricultural and veterinary sciences General Medicine Hepatitis B medicine.disease biology.organism_classification Magnetic Resonance Imaging Abdominal mass Ovarian neoplasm Marmota Woodchuck Female Histopathology medicine.symptom Tomography X-Ray Computed business Calcification |
| Zdroj: | BMC Veterinary Research |
| ISSN: | 1746-6148 |
| Popis: | Background Teratomas are germ cell neoplasms composed of a wide variety of tissues. In the woodchuck, only one testicular teratoma has been described in the literature. The objective of this report was to describe the radiologic and pathologic findings in a female woodchuck (Marmota monax) with an ovarian teratoma consisting of mature tissues originating from all three germ layers. Case presentation A 2-year-old female woodchuck that had been infected at birth with woodchuck hepatitis virus and subsequently developed hepatocellular carcinoma was incidentally discovered to have a mobile 6.6 × 4.8 × 4.7 cm abdominal mass on computed tomography (CT) imaging. The tumor was predominantly solid and heterogenous on CT with soft tissue, fat, and areas of dense calcification. The teratoma did not enhance with intravenous contrast administration. On ultrasound, the tumor was solid with heterogeneous echogenicity, reflecting the fat content and areas of calcification. Sonolucent areas were present that may have represented cysts. There was heterogeneously increased signal on T1-weighted magnetic resonance imaging (MRI) and heterogeneous hyperintensity in T2-weighted imaging. Fat was evident within the tumor. At necropsy, the tumor was attached to the distal end of the right uterine horn. Histopathology showed mature tissue types representing all three germ layers. Conclusions Ovarian teratoma should be considered in the differential diagnosis of ovarian or abdominal masses in woodchucks. The tumor displayed mature tissue derived from all three germ layers. CT, ultrasound, and MRI findings were presented in detail and matched the typical imaging appearance of teratomas. |
| Databáze: | OpenAIRE |
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