Evaluation of sex‐related hormones and semen characteristics in reproductive‐aged male COVID‐19 patients

Autor: Lei Shi, Jing Lyu, Hui Sun, Guangming Ye, Jyuling Qin, Zhimin Chen, Yuanzhen Zhang, Yao Xiong, Ming Zhang, Ling Ma, Fang Zheng, Danyang Li, Wen Xie, Yanhong Mao
Rok vydání: 2020
Předmět:
Zdroj: Journal of Medical Virology
ISSN: 1096-9071
0146-6615
Popis: In the past several months, the outbreak of SARS‐CoV‐2‐associated infection (coronavirus disease 2019, COVID‐19) developed rapidly and has turned into a global pandemic. Although SARS‐CoV‐2 mainly attacks respiratory systems, manifestations of multiple organs have been observed. Great concern was raised about whether COVID‐19 may affect male reproductive functions. In this study, we collected semen specimens from twelve male COVID‐19 patients for virus detection and semen characteristics analysis. No SARS‐CoV‐2 was found in semen specimens. 8 out of 12 patients had normal semen quality. We also compared the sex‐related hormone levels between 119 reproductive‐aged men with SARS‐CoV‐2 infection and 273 age‐matched control men. A higher serum luteinizing hormone (LH) and a lower ratio of testosterone (T) to LH were observed in the COVID‐19 group. Multiple regression analysis indicated that serum T:LH ratio was negatively associated with white blood cell counts (WBC) and c‐reactive protein (CRP) level in COVID‐19 patients. It's the first report about semen assessment and sex‐hormone evaluation in reproductive‐aged male COVID‐19 patients. Although further study is needed to clarify the reasons and underlying mechanisms, our study presents an abnormal sex hormone secretion among COVID‐19 patients, suggesting that attention should be paid to reproductive function evaluation in the follow‐up. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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