Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses
Autor: | Simo Saarakkala, Petri Lehenkari, Mikko A. J. Finnilä, Sakari S. Karhula, Tuomo Ylitalo, Maarit Valkealahti, Heikki Suhonen, Edward Hæggström, Harpal K. Gahunia, Heikki J. Nieminen, Kenneth P.H. Pritzker |
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Přispěvatelé: | Materials Physics, Department of Physics, University of Oulu, Orthopedic Science Consulting Services, University of Helsinki, University of Toronto, Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Aalto University |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Surface (mathematics)
Cartilage Articular Male microcomputed X-ray tomography 02 engineering and technology Surface finish Osteoarthritis Root mean square 0302 clinical medicine Surface roughness Orthopedics and Sports Medicine CT ARTHROGRAPHY Research Articles ULTRASOUND Aged 80 and over QUANTITATIVE ASSESSMENT Ultrasound Middle Aged medicine.anatomical_structure Female Tomography Research Article MRI Materials science 0206 medical engineering DIAGNOSIS 114 Physical sciences 03 medical and health sciences topography 3D imaging THICKNESS medicine ROUGHNESS Humans microcomputed X‐ray tomography articular cartilage ta217 Aged 030203 arthritis & rheumatology business.industry Fissure Phosphotungstic Acid X-Ray Microtomography QUANTIFICATION medicine.disease 3126 Surgery anesthesiology intensive care radiology 020601 biomedical engineering Cartilage OSTEOARTHRITIS surface roughness MORPHOLOGY business Biomedical engineering |
Zdroj: | Journal of Orthopaedic Research |
Popis: | One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently developed a contrast enhanced micro-computed tomography (mu CT) method for visualizing AC surface in detail. The present study aims to introduce a mu CT analysis technique to parameterize these complex AC surface features and to demonstrate the feasibility of using these parameters to quantify degenerated AC surface. Osteochondral plugs (n = 35) extracted from 19 patients undergoing joint surgery were stained with phosphotungstic acid and imaged using mu CT. The surface micro-topography of AC was analyzed with developed method. Standard root mean square roughness (R-q) was calculated as a reference, and the Area Under Curve (AUC) for receiver operating characteristic analysis was used to compare the acquired quantitative parameters with semi-quantitative visual grading of mu CT image stacks. The parameters quantifying the complex micro-topography of AC surface exhibited good sensitivity and specificity in identifying surface continuity (AUC: 0.93, [0.80 0.99]), fissures (AUC: 0.94, [0.83 0.99]) and fibrillation (AUC: 0.98, [0.88 1.0]). Standard R-q was significantly smaller compared with the complex roughness (CRq) already with mild surface changes with all surface reference parameters - continuity, fibrillation, and fissure sum. Furthermore, only CRq showed a significant difference when comparing the intact surface with lowest fissure sum score. These results indicate that the presented method for evaluating complex AC surfaces exhibit potential to identify early OA changes in superficial AC and is dynamic throughout OA progression. (c) 2019 The Authors. Journal of Orthopaedic Research (R) Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. Society. 9999:1-12, 2019. |
Databáze: | OpenAIRE |
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