Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses

Autor: Simo Saarakkala, Petri Lehenkari, Mikko A. J. Finnilä, Sakari S. Karhula, Tuomo Ylitalo, Maarit Valkealahti, Heikki Suhonen, Edward Hæggström, Harpal K. Gahunia, Heikki J. Nieminen, Kenneth P.H. Pritzker
Přispěvatelé: Materials Physics, Department of Physics, University of Oulu, Orthopedic Science Consulting Services, University of Helsinki, University of Toronto, Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Aalto University
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Surface (mathematics)
Cartilage
Articular

Male
microcomputed X-ray tomography
02 engineering and technology
Surface finish
Osteoarthritis
Root mean square
0302 clinical medicine
Surface roughness
Orthopedics and Sports Medicine
CT ARTHROGRAPHY
Research Articles
ULTRASOUND
Aged
80 and over

QUANTITATIVE ASSESSMENT
Ultrasound
Middle Aged
medicine.anatomical_structure
Female
Tomography
Research Article
MRI
Materials science
0206 medical engineering
DIAGNOSIS
114 Physical sciences
03 medical and health sciences
topography
3D imaging
THICKNESS
medicine
ROUGHNESS
Humans
microcomputed X‐ray tomography
articular cartilage
ta217
Aged
030203 arthritis & rheumatology
business.industry
Fissure
Phosphotungstic Acid
X-Ray Microtomography
QUANTIFICATION
medicine.disease
3126 Surgery
anesthesiology
intensive care
radiology

020601 biomedical engineering
Cartilage
OSTEOARTHRITIS
surface roughness
MORPHOLOGY
business
Biomedical engineering
Zdroj: Journal of Orthopaedic Research
Popis: One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently developed a contrast enhanced micro-computed tomography (mu CT) method for visualizing AC surface in detail. The present study aims to introduce a mu CT analysis technique to parameterize these complex AC surface features and to demonstrate the feasibility of using these parameters to quantify degenerated AC surface. Osteochondral plugs (n = 35) extracted from 19 patients undergoing joint surgery were stained with phosphotungstic acid and imaged using mu CT. The surface micro-topography of AC was analyzed with developed method. Standard root mean square roughness (R-q) was calculated as a reference, and the Area Under Curve (AUC) for receiver operating characteristic analysis was used to compare the acquired quantitative parameters with semi-quantitative visual grading of mu CT image stacks. The parameters quantifying the complex micro-topography of AC surface exhibited good sensitivity and specificity in identifying surface continuity (AUC: 0.93, [0.80 0.99]), fissures (AUC: 0.94, [0.83 0.99]) and fibrillation (AUC: 0.98, [0.88 1.0]). Standard R-q was significantly smaller compared with the complex roughness (CRq) already with mild surface changes with all surface reference parameters - continuity, fibrillation, and fissure sum. Furthermore, only CRq showed a significant difference when comparing the intact surface with lowest fissure sum score. These results indicate that the presented method for evaluating complex AC surfaces exhibit potential to identify early OA changes in superficial AC and is dynamic throughout OA progression. (c) 2019 The Authors. Journal of Orthopaedic Research (R) Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. Society. 9999:1-12, 2019.
Databáze: OpenAIRE
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