14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae
| Autor: | Jesmond Dalli, Oliver Werz, Duco S. Koenis, Hans Jagusch, Georg Pohnert, Markus Werner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
chemistry.chemical_classification 0303 health sciences biology 010405 organic chemistry Eicosatetraenoic acid fungi Lipid signaling biology.organism_classification 01 natural sciences 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound Cylindrotheca closterium chemistry Biochemistry Algae Pharmacology (medical) Function (biology) 030304 developmental biology Polyunsaturated fatty acid |
| Zdroj: | ACS Pharmacol Transl Sci |
| ISSN: | 2575-9108 |
| DOI: | 10.1021/acsptsci.1c00057 |
| Popis: | [Image: see text] Specialized pro-resolving mediators (SPMs) are enzymatically oxygenated derivatives of polyunsaturated fatty acids that function as central immunoregulators in mammals. Among them are resolvins (Rvs) that stimulate the clearance of harmful stimuli and limit pro-inflammatory processes. Because of their beneficial features and their high potency, SPMs are promising molecules for anti-inflammatory therapy. Besides mammals, also marine algae form lipid mediators such as prostaglandins and leukotrienes. In particular, microalgae are attractive candidates for the production of bioactive high-value metabolites. Here, we identified the diatom Cylindrotheca closterium as a prolific producer of SPMs. The diatom forms RvE3 and novel structurally related eicosanoids, including 14S/R,17R,18R-trihydroxy-eicosatetraenoic acid, which displays inflammation-resolving and anti-inflammatory bioactivities. This pro-resolving compound might enable advancements in anti-inflammatory therapy in mammals. |
| Databáze: | OpenAIRE |
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