Acyl Ghrelin and Metabolic Hormones in Pregnant and Lactating Sows
| Autor: | Uberto Pagotto, P. Penazzi, Carlo Tamanini, Eraldo Seren, Giovanna Galeati, Nadia Govoni, R. De Iasio, Albamaria Parmeggiani, Renato Pasquali |
|---|---|
| Přispěvatelé: | Govoni N, Parmeggiani A, Galeati G, Penazzi P, De Iasio R, Pagotto U, Pasquali R, Tamanini C, Seren E. |
| Rok vydání: | 2007 |
| Předmět: |
Leptin
medicine.medical_specialty Time Factors Swine Peptide Hormones Weaning Fatty Acids Nonesterified Biology PREGNANT AND LACTATING SOWS Endocrinology NEFA Pregnancy Internal medicine Lactation medicine Animals ACYL GHRELIN Insulin-Like Growth Factor I METABOLIC HORMONES Estrous cycle digestive oral and skin physiology Radioimmunoassay Ghrelin medicine.anatomical_structure Growth Hormone Pregnancy Animal Female Animal Science and Zoology Secretagogue hormones hormone substitutes and hormone antagonists Biotechnology Hormone |
| Zdroj: | Reproduction in Domestic Animals. 42:39-43 |
| ISSN: | 1439-0531 0936-6768 |
| DOI: | 10.1111/j.1439-0531.2006.00722.x |
| Popis: | Contents Ghrelin, the endogenous ligand of the growth hormone (GH) secretagogue receptor, is considered a pleiotropic regulator involved in a large array of functions, including control of energy balance, regulation of food intake and, more recently, modulation of the reproductive axis. The present study was aimed at determining the changes in plasma concentrations of acyl-ghrelin in pregnant and lactating sows, with special emphasis on the relationship with the levels of GH, leptin, non-esterified fatty acids (NEFA) and insulin-like growth factor (IGF-1). Blood samples were collected via jugular venipuncture from 22 multiparous sow 30, 60 and 90 days after artificial insemination, 7 and 21 days after farrowing and at first oestrus post-weaning. Plasma concentrations of acyl-ghrelin, leptin, GH and IGF-1 were quantified by validated radioimmunoassay; NEFA were determined using a colorimetric procedure. Plasma acyl ghrelin levels were highest at 30 days of pregnancy and decreased thereafter and during lactation. At the beginning of lactation, GH, IGF-1 and NEFA concentrations significantly increased, while a significant reduction occurred in leptin. In conclusion, ghrelin concentrations in sow maternal circulation does not seem to play an important role in maintaining circulating GH levels during lactation; moreover, ghrelin is not associated with leptin, NEFA and IGF-1 levels. |
| Databáze: | OpenAIRE |
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