Hemoglobin-Acetaldehyde Adducts in Human Volunteers Following Acute Ethanol Ingestion
| Autor: | Onni Niemelä, Yedy Israel, C. J. Peter Eriksson, Tatsushige Fukunaga, Yasuhiko Mizoi |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Medicine (miscellaneous) Enzyme-Linked Immunosorbent Assay Acetaldehyde Toxicology chemistry.chemical_compound In vivo Internal medicine Flushing medicine Humans Ingestion Ethanol metabolism Volunteer Ethanol Hemoglobin A Psychiatry and Mental health Endocrinology chemistry Biochemistry Toxicity Female Hemoglobin Alcoholic Intoxication Protein Binding |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 14:838-841 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.1990.tb01824.x |
| Popis: | Rabbit antibodies against albumin-acetaldehyde adduct were used in an enzyme-linked immunosorbent assay to detect acetaldehyde-hemoglobin condensates from the blood of 12 volunteers following ingestion of 1.3 to 2.9 g of ethanol per kg body weight during 8 hr. Blood samples were drawn before drinking and between 2 to 46 hr after starting the drinking session. While there were no significant increases in blood acetaldehyde levels in these samples, acetaldehyde-hemoglobin adducts were significantly increased in the samples drawn after ethanol had been eliminated from the body. Administration of ethanol (0.1 g/kg) to an Oriental flusher resulted in an increase both in blood acetaldehyde and the hemoglobin-acetaldehyde adduct levels. These results suggest that acetaldehyde-hemoglobin condensates are formed in vivo following acute ethanol ingestion. Such condensates may be of value to mark alcohol consumption. |
| Databáze: | OpenAIRE |
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