Absence of Motor-Evoked Potentials Does Not Predict Poor Recovery in Patients With Severe-Moderate Stroke: An Exploratory Analysis
| Autor: | Larry B. Goldstein, Lumy Sawaki, Philip M. Westgate, Elizabeth Salmon Powell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Rehabilitation hospital
medicine.medical_specialty PNS peripheral nerve stimulation medicine.medical_treatment FMA Fugl-Meyer Assessment ARAT Action Research Arm Test Physical medicine and rehabilitation medicine Stroke Original Research MCID minimal clinically important difference lcsh:R5-920 Rehabilitation Transcranial direct-current stimulation business.industry BMI brain-machine interface Minimal clinically important difference TMS transcranial magnetic stimulation Repeated measures design MEP motor-evoked potential General Medicine tDCS transcranial direct current stimulation medicine.disease MSO maximum stimulator output Neuromodulation (medicine) Transcranial magnetic stimulation Transcranial direct current stimulation business lcsh:Medicine (General) |
| Zdroj: | Archives of Rehabilitation Research and Clinical Translation Archives of Rehabilitation Research and Clinical Translation, Vol 1, Iss 3, Pp-(2019) |
| ISSN: | 2590-1095 |
| Popis: | Objective: To better understand the role of the presence or absence of motor-evoked potentials (MEPs) in predicting functional outcomes following a severe-moderate stroke. Design: Retrospective exploratory analysis. We compared the effects of the stimulation condition (active or sham), MEP status (+ or −), and a combination of stimulation condition and MEP status on outcome. Within-group and between-group changes were assessed with longitudinal repeated measures analysis of variance and longitudinal repeated measures analysis of covariance, respectively. The proportions of participants who achieved minimal clinically important differences (MCIDs) for the main outcome measures were calculated. Setting: University research laboratory within a rehabilitation hospital. Participants: A total of 129 subjects with severe-moderate stroke-related motor impairments who participated in previous studies combining neuromodulation and motor training Interventions: Neuromodulation (active or sham) and motor training. Main Outcome Measures: Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT). Results: When participants were grouped by stimulation condition or MEP status, all groups improved from baseline to immediate postintervention and follow-up evaluations (all P.05). Regarding MCIDs, in the MEP−/active group, 14.5% of individuals reached MCID on FMA and 8.3% on ARAT post intervention. In the MEP+/active group, 33.3% of individuals reached MCID on FMA and 27.3% on ARAT post intervention. Conclusion: As expected, the MEP+ group had the greatest improvement in motor function. However, it was shown that individuals without MEPs can also achieve meaningful changes, as reflected by MCID, when neuromodulation is paired with motor training. To our knowledge, this is the first study to differentiate the effects of neuromodulation by MEP status. Keywords: Rehabilitation, Transcranial direct current stimulation, Transcranial magnetic stimulation |
| Databáze: | OpenAIRE |
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