Protein binding of enprofylline
| Autor: | I. Svensson, O. Borgå, K. Tegnér |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.drug_class
Ultrafiltration Plasma protein binding chemistry.chemical_compound Dogs Species Specificity Theophylline Bronchodilator Albumins Blood plasma medicine Animals Humans Pharmacology (medical) Equilibrium dialysis Pharmacology Chromatography Chemistry Temperature General Medicine Metabolism Blood Proteins Haplorhini Hydrogen-Ion Concentration Rats Ultrafiltration (renal) Xanthines Enprofylline Dialysis medicine.drug Protein Binding |
| Zdroj: | European journal of clinical pharmacology. 25(5) |
| ISSN: | 0031-6970 |
| Popis: | The protein binding of enprofylline, 3-propylxanthine, in plasma was studied by equilibrium dialysis and ultrafiltration under various experimental conditions. A limited comparison with theophylline was also undertaken. The mean fraction of enprofylline bound in human plasma at 20 degrees C was 47.3 +/- 1.1% (SD), which was only 2% less than theophylline. The binding of the two drugs increased dramatically in the pH range 7.2 to 7.8, as reported previously for theophylline. Reasonable agreement was found between equilibrium dialysis and ultrafiltration, but the latter technique proved impractical, because pH control was difficult to achieve. A pronounced species difference in the binding of enprofylline was found. At pH 7.4 an almost constant level of binding of 57% in dog and 81% in rat was found up to 2.10(-5) M (approx. 4 mg/l). Corresponding values in human and monkey plasma were 47 and 48%, respectively, up to 10(-4) M (approx. 20 mg/l). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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