Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial
| Autor: | Hui Peng, Nanqi Huang, Yanxing Luo, Huanlong Qin, Ping Lan, Liang Kang, Zhihua Liu, Meijin Huang, Xiaojian Wu, Peng Zhang, Chao Li, Junsheng Peng, Jianping Wang, Lei Wang, Chao Tong, Xingwei Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Colorectal cancer medicine.medical_treatment p38 Mitogen-Activated Protein Kinases Medicine Intestinal Mucosa Colectomy Aged 80 and over Liver Neoplasms Gastroenterology Zonulin General Medicine Bacterial Infections Middle Aged Urinary Tract Infections Female Colorectal Neoplasms Research Article Signal Transduction Adult DNA Bacterial medicine.medical_specialty Cholera Toxin Perioperative Care Permeability Double-Blind Method Internal medicine Sepsis Hepatectomy Humans Protein Precursors Aged Intestinal permeability Haptoglobins business.industry Probiotics Postoperative complication Perioperative Hepatology medicine.disease Surgery Colorectal liver metastases Endotoxins Intestinal Diseases Intraabdominal Infections business Liver barrier |
| Zdroj: | BMC Gastroenterology |
| ISSN: | 1471-230X |
| Popis: | Background Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration of probiotics on serum zonulin levels which is a marker of intestinal permeability and the subsequent impact on postoperative infectious complications in patients with CLM. Methods 150 patients with CLM were randomly divided into control group (n = 68) and probiotics group (n = 66). Probiotics and placebo were given orally for 6 days preoperatively and 10 days postoperatively to control group and probiotics group respectively. We used the local resection for metastatic tumor ,while for large tumor, the segmental hepatectomy. Postoperative outcome were recorded. Furthermore, complications in patients with normal intestinal barrier function and the relation with serum zonulin were analyzed to evaluate the impact on the liver barrier dysfunction. Results The incidence of infectious complications in the probiotics group was lower than control group. Analysis of CLM patients with normal postoperative intestinal barrier function paralleled with the serum zonulin level. And probiotics could also reduce the concentration of serum zonulin (P = 0.004) and plasma endotoxin (P |
| Databáze: | OpenAIRE |
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