Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
| Autor: | Sarah Laxhmi Chellappa, Christophe Phillips, Amaury Vanvinckenroye, Gilles Vandewalle |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nerve net media_common.quotation_subject Models Neurological Review Article Electroencephalography lcsh:RC321-571 03 medical and health sciences Cognition 0302 clinical medicine Neuroplasticity medicine Humans Computer Simulation Wakefulness lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry media_common Computational model medicine.diagnostic_test Dynamic causal modelling Brain Human brain Circadian Rhythm 030104 developmental biology medicine.anatomical_structure Neurology Neurology (clinical) Nerve Net Consciousness Sleep Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neural Plasticity, Vol 2016 (2016) Neural Plasticity |
| ISSN: | 1687-5443 2090-5904 |
| Popis: | Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space. On a much longer time scale, brain function also depends on prior sleep-wake history and circadian processes. However, much remains to be established on how the brain operates at the neuronal level in humans during sleep and wakefulness. A key limitation of human neuroscience is the difficulty in isolating neuronal excitation/inhibition drive in vivo. Therefore, computational models are noninvasive approaches of choice to indirectly access hidden neuronal states. In this review, we present a physiologically driven in silico approach, Dynamic Causal Modelling (DCM), as a means to comprehend brain function under different experimental paradigms. Importantly, DCM has allowed for the understanding of how brain dynamics underscore brain plasticity, cognition, and different states of consciousness. In a broader perspective, noninvasive computational approaches, such as DCM, may help to puzzle out the spatial and temporal dynamics of human brain function at different behavioural states. |
| Databáze: | OpenAIRE |
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