Microwave Assisted Attractive and Rapid Process for Synthesis of Octahydroquinazolinone in Aqueous Hydrotropic Solutions

Autor:	Rajshri Salunkhe, Arjun Kumbhar, Sanjay Jadhav, Santosh Kamble
Rok vydání:	2014
Předmět:	Aqueous solution Aryl Aqueous Medium Octahydroquinazolinone Hydrotrope Context (language use) General Medicine Condensation reaction Toluene chemistry.chemical_compound Sulfonate chemistry Dimedone Organic chemistry Microwave
Zdroj:	Procedia Materials Science. 6:1850-1856
ISSN:	2211-8128
DOI:	10.1016/j.mspro.2014.07.215
Popis:	We demonstrate here the synthesis of octahydroquinazolinone derivatives through one-pot, three-component condensation reactions of various aryl aldehydes, with a dimedone and urea in 50% aqueous hydrotropic solution (Sodium p -Toluene Sulfonate) under microwave irradiation. This method exhibits efficient and environmentally benign methodology with simple reaction workup for the rapid synthesis of library of octahydroquinazolinones. Moreover, the reaction medium can be easily separated from the product and subsequently reused many times. The present method is of great interest in the context of environmentally greener and safer processes.
Databáze:	OpenAIRE
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