Molecular signatures of atherosclerotic plaques: An up-dated panel of protein related markers
| Autor: | Sara Eslava-Alcon, Jose Angel Alonso-Piñero, Manuel Rodriguez-Piñero, Francisco García-Cózar, Esther Doiz, Almudena González-Rovira, Ismael Sánchez-Gomar, Margarita Jimenez-Palomares, Lucía Beltrán-Camacho, G. Alvarez-Llamas, E. Lozano, Mª Carmen Duran-Ruiz, Rosario Conejero, Mª Jesús Extremera-García, Antonio Rosal-Vela, Marta Rojas-Torres, J. Olarte, A. Foncubierta-Fernández |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Proteomics Pathology medicine.medical_specialty Biophysics Inflammation Biochemistry Extracellular matrix 03 medical and health sciences medicine Humans Myocardial infarction Clinical imaging Stroke 030102 biochemistry & molecular biology business.industry Plaque rupture medicine.disease Atherosclerosis Protein markers Plaque Atherosclerotic 030104 developmental biology medicine.symptom business Biomarkers |
| Zdroj: | Journal of proteomics. 221 |
| ISSN: | 1876-7737 |
| Popis: | Atherosclerosis remains the leading cause of ischemic syndromes such as myocardial infarction or brain stroke, mainly promoted by plaque rupture and subsequent arterial blockade. Identification of vulnerable or high-risk plaques constitutes a major challenge, being necessary to identify patients at risk of occlusive events in order to provide them with appropriate therapies. Clinical imaging tools have allowed the identification of certain structural indicators of prone-rupture plaques, including a necrotic lipidic core, intimal and adventitial inflammation, extracellular matrix dysregulation, and smooth muscle cell depletion and micro-calcification. Additionally, alternative approaches focused on identifying molecular biomarkers of atherosclerosis have also been applied. Among them, proteomics has provided numerous protein markers currently investigated in clinical practice. In this regard, it is quite uncertain that a single molecule can describe plaque rupture, due to the complexity of the process itself. Therefore, it should be more accurate to consider a set of markers to define plaques at risk. Herein, we propose a selection of 76 proteins, from classical inflammatory to recently related markers, all of them identified in at least two proteomic studies analyzing unstable atherosclerotic plaques. Such panel could be used as a prognostic signature of plaque instability. |
| Databáze: | OpenAIRE |
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