Effects of Histone Modification in Major Depressive Disorder
| Autor: | Mansi Wu, Jiaxu Chen, Qiuyue Xu, Simeng Gu, Chenyue Liu, Junqing Huang, Xiaojuan Li |
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| Rok vydání: | 2022 |
| Předmět: |
Disease
Bioinformatics behavioral disciplines and activities Histones mental disorders Histone methylation medicine Humans Pharmacology (medical) Pharmacology Depressive Disorder Major biology business.industry Mechanism (biology) Acetylation General Medicine medicine.disease Histone Code Histone Deacetylase Inhibitors Psychiatry and Mental health Histone phosphorylation Histone Neurology biology.protein Major depressive disorder Neurology (clinical) Histone deacetylase business Protein Processing Post-Translational |
| Zdroj: | Current Neuropharmacology. 20:1261-1277 |
| ISSN: | 1570-159X |
| Popis: | Major depressive disorder (MDD) is a disease associated with many factors; specifically, environmental, genetic, psychological, and biological factors play critical roles. Recent studies have demonstrated that histone modification may occur in the human brain in response to severely stressful events, resulting in transcriptional changes and the development of MDD. In this review, we discuss five different histone modifications, histone methylation, histone acetylation, histone phosphorylation, histone crotonylation and histone β-hydroxybutyrylation, and their relationships with MDD. The utility of histone deacetylase (HDAC) inhibitors (HDACis) for MDD treatment is also discussed. As a large number of MDD patients in China have been treated with traditional Chineses medicine (TCM), we also discuss some TCM therapies, such as Xiaoyaosan (XYS), and their effects on histone modification. In summary, targeting histone modification may be a new strategy for elucidating the mechanism of MDD and a new direction for MDD treatment. |
| Databáze: | OpenAIRE |
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