The potential of Quercetin to protect against loperamide‐induced constipation in rats
| Autor: | Wenhui Liu, Aimin Zhi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
signal pathways Loperamide loperamide TRPV1 Substance P Pharmacology Motilin 03 medical and health sciences symbols.namesake chemistry.chemical_compound 0302 clinical medicine Glial cell line-derived neurotrophic factor medicine TX341-641 rat Original Research biology Nutrition. Foods and food supply constipation Interstitial cell of Cajal Nitric oxide synthase 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein symbols Quercetin Food Science medicine.drug |
| Zdroj: | Food Science & Nutrition Food Science & Nutrition, Vol 9, Iss 6, Pp 3297-3307 (2021) |
| ISSN: | 2048-7177 |
| DOI: | 10.1002/fsn3.2296 |
| Popis: | Constipation is the most common gastrointestinal complaint all over the world, and it is a risk factor of colorectal cancer. In this study, the protective of Quercetin against loperamide‐induced constipation and its potential mechanism in a rat model were investigated. Results showed that Quercetin at 25 mg/kg and 50 mg/kg could significantly (p Quercetin exerted a protective effect against loperamide‐induced constipation. The possible protective mechanisms of Quercetin might involve the innate immune response via modulating the c‐kit/SCF pathway and other pathways. |
| Databáze: | OpenAIRE |
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