Intermuscular adipose tissue and thigh muscle area dynamics during an 18-month randomized weight loss trial
| Autor: | Dan Schwarzfuchs, Dana Serfaty, Hila Zelicha, Avital Bilitzky, Nitzan Bril, Meir J. Stampfer, Shira Kenigsbuch, Noa Cohen, Matthias Blüher, Uta Ceglarek, Michal Rein, Anat Yaskolka Meir, Yoash Chassidim, Lilac Tene, Lior Zeller, Ilan Shelef, Assaf Rudich, Iris Shai, Joachim Thiery, Gal Tsaban, Yftach Gepner, Michael Stumvoll, Oded Komy |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Waist Physiology Abdominal Fat Adipose tissue 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Weight loss Physiology (medical) Internal medicine Weight Loss Humans Medicine Longitudinal Studies Obesity Muscle Skeletal Abdominal obesity Creatinine business.industry Leptin Organ Size Middle Aged medicine.disease Endocrinology Thigh chemistry Obesity Abdominal Basal metabolic rate Female medicine.symptom business |
| Zdroj: | Journal of Applied Physiology. 121:518-527 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00309.2016 |
| Popis: | It remains unclear whether intermuscular adipose tissue (IMAT) has any metabolic influence or whether it is merely a marker of abnormalities, as well as what are the effects of specific lifestyle strategies for weight loss on the dynamics of both IMAT and thigh muscle area (TMA). We followed the trajectory of IMAT and TMA during 18-mo lifestyle intervention among 278 sedentary participants with abdominal obesity, using magnetic resonance imaging. We measured the resting metabolic rate (RMR) by an indirect calorimeter. Among 273 eligible participants (47.8 ± 9.3 yr of age), the mean IMAT was 9.6 ± 4.6 cm2. Baseline IMAT levels were directly correlated with waist circumference, abdominal subdepots, C-reactive protein, and leptin and inversely correlated with baseline TMA and creatinine ( P < 0.05 for all). After 18 mo (86.3% adherence), both IMAT (−1.6%) and TMA (−3.3%) significantly decreased ( P < 0.01 vs. baseline). The changes in both IMAT and TMA were similar across the lifestyle intervention groups and directly corresponded with moderate weight loss ( P < 0.001). IMAT change did not remain independently associated with decreased abdominal subdepots or improved cardiometabolic parameters after adjustments for age, sex, and 18-mo weight loss. In similar models, 18-mo TMA loss remained associated with decreased RMR, decreased activity, and with increased fasting glucose levels and IMAT ( P < 0.05 for all). Unlike other fat depots, IMAT may not represent a unique or specific adipose tissue, instead largely reflecting body weight change per se. Moderate weight loss induced a significant decrease in thigh muscle area, suggesting the importance of resistance training to accompany weight loss programs. |
| Databáze: | OpenAIRE |
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