The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats
| Autor: | Y Vahedi, T. Samadian, M. E. Zolfaghari, Ahmad Reza Dehpour |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Analgesic Carbenoxolone Pharmaceutical Science Pharmacology Ulcer index law.invention chemistry.chemical_compound law Internal medicine medicine Glycyrrhiza Animals Stomach Ulcer Rats Wistar Enoxolone Dosage Forms Aspirin Plants Medicinal business.industry Plant Extracts Stomach Rats Endocrinology medicine.anatomical_structure chemistry Toxicity Glycyrrhetinic Acid Phytotherapy business medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 46(2) |
| ISSN: | 0022-3573 |
| Popis: | We have examined the protective effect of liquorice or its derivatives against gastric ulcer induced by aspirin. A granular mixture of aspirin alone and coated with liquorice or its derivatives including the deglycyrrhized form, a high glycyrrhized form, carbenoxolone, and enoxolone were studied. Aspirin coated with liquorice reduced the number and size of ulcers, reducing the ulcer index from 1·5±0·12 to 0·5 ± 0·12 and the incidence from 96% to 46%. Coating with derivatives was less effective (ulcer index, 0·70–0·94; incidence 62–76%). |
| Databáze: | OpenAIRE |
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