Cardiovascular drugs attenuated myocardial resistance against ischaemia-induced and reperfusion-induced injury in a rat model of repetitive occlusion
| Autor: | Nora Gatzke, Nadija Güc, André Dülsner, Ferdinand le Noble, Eva Buschmann, Philipp Hillmeister, Maja Ingwersen, Ivo Buschmann, Peter Bramlage |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Life sciences biology medicine.medical_specialty 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences beta-blockers 0302 clinical medicine Internal medicine ddc:570 medicine Myocardial infarction cardiovascular diseases collateral circulation ranolazine Metoprolol calcium channel blockers angiotensin II receptor blockers business.industry Correction medicine.disease Collateral circulation reperfusion injury Cardiac Risk Factors and Prevention nitroglycerine Candesartan myocardial ischemia 030104 developmental biology myocardial infarction ischemic preconditioning arteriogenesis Cardiology cardiovascular system Ischemic preconditioning Verapamil Cardiology and Cardiovascular Medicine business Reperfusion injury coronary artery disease medicine.drug |
| Zdroj: | Open Heart, 5 (2), e000889 Open Heart |
| ISSN: | 2053-3624 |
| DOI: | 10.5445/ir/1000104148 |
| Popis: | ObjectiveWe investigated the impact of cardioprotective drugs on ST-elevation, arrhythmias and infarct size in a rat model of repetitive coronary artery occlusion.MethodsSeventy Sprague-Dawley rats were randomised to two control and five treatment groups. Placebo was either implantation of a pneumatic occluder onto the left anterior descending coronary artery (LAD) without starting repetitive occlusion (SHAM) or subsequent RO of the LAD over 10 days without medication (ROP). Treatment groups underwent RO and additionally received nitroglycerin (NTG), metoprolol, verapamil (VER), ranolazine (RAN) or candesartan (CAN). Two weeks after the intervention, rats underwent a single, sustained LAD occlusion followed by reperfusion. To evaluate differences in cardiac resistance against myocardial ischaemia and reperfusion injury, cardiac surrogate parameters including maximal ST-elevation, arrhythmias and infarct size were assessed.ResultsCompared with sham, RO alone and RO plus nitroglycerin were associated with significantly lower maximal ST-elevation and percentage of infarcted myocardium (SHAM 0.12 mV, ROP 0.06 mV (p=0.004), NTG 0.05 mV (p=0.005); SHAM 16.2%, ROP 6.6% (p=0.008), NTG 5.9% (p=0.006). Compared with RO alone, RO plus RAN was accompanied by increased ST-elevation (0.13 mV, p=0.018) and RO plusVER or CAN by more infarcted myocardium (14.2%, p=0.004% and 15.5%, p=0.003, respectively). Rats treated with VER, RAN or CAN tended to severe arrhythmias more frequently than those of the control groups.ConclusionsRO led to an increased myocardial resistance against ischaemia and reperfusion injury. Concomitant administration of nitroglycerin did not affect the efficacy of RO. Cardiovascular channel or receptor blockers reduced the efficacy of RO. |
| Databáze: | OpenAIRE |
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