Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy
| Autor: | Hongyu Lin, Jinhao Gao, Xuanqing Gong, Liyun Su, Xiaomei Yan, Xiangjie Luo, Zhaoxuan Yang |
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| Rok vydání: | 2020 |
| Předmět: |
Mitochondrial ROS
Chemotherapy 010405 organic chemistry business.industry medicine.medical_treatment Cancer General Chemistry General Medicine Prodrug Mitochondrion 010402 general chemistry medicine.disease 01 natural sciences Catalysis 0104 chemical sciences Mitochondria Apoptosis In vivo Neoplasms Cancer cell medicine Cancer research Prodrugs business Energy Metabolism |
| Zdroj: | Angewandte Chemie (International ed. in English). 60(3) |
| ISSN: | 1521-3773 |
| Popis: | Despite widespread applications for cancer treatment, chemotherapy is restricted by several limitations, including low targeting specificity, acquired drug resistance, and concomitant adverse side effects. It remains challenging to overcome these drawbacks. Herein, we report a new bioenergetic approach for treating cancer efficiently. As a proof-of-concept, we construct activatable mitochondria-targeting organoarsenic prodrugs from organoarsenic compounds and traditional chemotherapeutics. These prodrugs could accomplish selective delivery and controlled release of both therapeutic agents to mitochondria, which synergistically promote mitochondrial ROS production and induce mitochondrial DNA damage, finally leading to mitochondria-mediated apoptosis of cancer cells. Our in vitro and in vivo experiments reveal the excellent anticancer efficacy of these prodrugs, underscoring the encouraging outlook of this strategy for effective cancer therapy. |
| Databáze: | OpenAIRE |
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