Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides
| Autor: | Neeraj Kumar Fuloria, Mohammad Shaharyar, Mohammad Babar Ali, Vijender Singh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Antifungal
Azides medicine.drug_class Pharmaceutical Science Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry phenylpropionohydrazide Anti-Infective Agents Drug Discovery medicine Organic chemistry Molecule Physical and Theoretical Chemistry Oxadiazoles Molecular Structure Communication Organic Chemistry Antimicrobial Combinatorial chemistry Acetic anhydride antibacterial chemistry Chemistry (miscellaneous) imines Molecular Medicine antifungal |
| Zdroj: | Molecules Molecules, Vol 14, Iss 5, Pp 1898-1903 (2009) |
| ISSN: | 1420-3049 |
| Popis: | In this study a series of new 1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a) and 1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b) were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles. |
| Databáze: | OpenAIRE |
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