Effect of Selenium on Brain Injury in Chickens with Subacute Arsenic Poisoning
| Autor: | Qiang Wu, Guilin Jia, Zhihua Ren, Junliang Deng, Youtian Deng, Ling Zhu, Niao Wen, Zhicai Zuo, Huidan Deng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry 010501 environmental sciences medicine.disease_cause 01 natural sciences Biochemistry Nitric oxide Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Selenium Internal medicine Arsenic Poisoning medicine Animals 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences Arsenic toxicity biology Glutathione peroxidase 030302 biochemistry & molecular biology Biochemistry (medical) Glutamate receptor Broiler General Medicine Glutathione Nitric oxide synthase Endocrinology chemistry Brain Injuries biology.protein Acetylcholinesterase Chickens Oxidative stress |
| Zdroj: | Biological trace element research. 200(1) |
| ISSN: | 1559-0720 |
| Popis: | The aim of this study was to investigate the effects of different doses of selenium (Se) on oxidative damage and neurotransmitter-related parameters in arsenic (As)-induced broiler brain tissue damage. Two hundred 1-day-old avian broilers were randomly divided into five groups and fed the following diets: control group (As 0.1 mg/kg + Se 0.2 mg/kg), As group (As 3 mg/kg + Se 0.2 mg/kg), low-Se group (As 3 mg/kg + Se 5 mg/kg), medium-Se group (As 3 mg/kg + Se 10 mg/kg), and high-Se group (As 3 mg/kg + Se 15 mg/kg). Glutathione (GSH), glutathione peroxidase (GSH-PX), nitric oxide (NO), nitric oxide synthase (NOS) activity, glutamate (Glu) concentration, glutamine synthetase (GS) activity, acetylcholinesterase (TchE) activity, and the apoptosis rate of brain cells were measured. The results showed that 3 mg/kg dietary As could induce oxidative damage and neurotransmitter disorder of brain tissue, increase the apoptosis rate of brain cells and cause damage to brain tissue, decrease activities of GSH and GSH-PX, decrease the contents of NO, decrease the activities of iNOS and tNOS, increase contents of Glu, and decrease activities of Gs and TchE. Compared with the As group, the Se addition of the low-Se and medium-Se groups protected against As-induced oxidative damage, neurotransmitter disorders, and the apoptosis rate of brain cells, with the addition of 10 mg/kg Se having the best effect. However, 15 mg/kg Se not only did not produce a protective effect against As damage but actually caused similar or severe damage. |
| Databáze: | OpenAIRE |
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