PLoS ONE
| Autor: | Hamdy F. F. Mahmoud, Safaa A. A. Khaled |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Visual Analog Scale Physiology Biochemistry Severity of Illness Index Arthritis Rheumatoid Hemoglobins Medical Conditions Skeletal Joints Animal Cells Medicine and Health Sciences Medicine Platelet Musculoskeletal System Multidisciplinary medicine.diagnostic_test Platelet Distribution Width Remission Induction Hematology Middle Aged C-Reactive Proteins Ankle Joints Body Fluids medicine.anatomical_structure Blood C-Reactive Protein Rheumatoid arthritis Erythrocyte sedimentation rate Legs Female Anatomy Cellular Types Mean Platelet Volume Research Article Platelets Adult Blood Platelets medicine.medical_specialty Visual analogue scale Science Inflammatory Diseases Immunology Rheumatoid Arthritis Blood Sedimentation Autoimmune Diseases Rheumatology Internal medicine Humans Platelet activation Mean platelet volume Skeleton Blood Cells business.industry Platelet Count Arthritis Ankles Biology and Life Sciences Proteins Reproducibility of Results Cell Biology medicine.disease Body Limbs Case-Control Studies Clinical Immunology Ankle Clinical Medicine business Ankle Joint Biomarkers |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 9, p e0257200 (2021) |
| Popis: | BackgroundPlatelet indices (PIs) are platelet parameters that are correlated with platelet activity. Despite being widely available, inexpensive, and feasible; their use in clinical settings is limited. Recently, we developed a new score (EgyDAS), which relies on PIs and assesses disease activity in rheumatoid arthritis (RA).ObjectivesThis study explored the practicability and validity of EgyDAS in RA with ankle involvement, considering that ankle is neglected in the commonly used DAS28 score.MethodsThis comparative case-control study included 2-groups of RA patients, group1 (control): without and group 2: with ankle involvement.ResultsAnkle involvement in RA showed no gender or age differences, however, it was associated with higher platelet count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet distribution width (PDW), visual analogue scale (VAS), tender joint count (TJC), and lower hemoglobin (Hb) and mean platelet volume (MPV). DAS28 categorized a higher proportion of patients to have high disease activity compared with EgyDAS; moreover, it did not detect those in remission in group 2 patients. Highly significant differences in the 2-scores were observed between the two groups. Further analyses revealed superiority of EgyDAS in assessing disease activity in group 2 patients. Finally, both scores were found correlated together in the study groups.ConclusionsOver or underestimation of RA disease activity could occur when using DAS28. PIs were found correlated with ankle involvement in RA. PIs and EgyDAS are the best tools to assess disease activity in RA patients with ankle involvement. However, the study recommended the use of both scores together. |
| Databáze: | OpenAIRE |
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