Reverse Arterial Blood Flow as a Pathway for Central Nervous System Toxic Responses Following Injection of Local Anesthetics
| Autor: | J. Aldrete, Satish Arora, Francisco Romo-Salas, Rodger Wilson, Robert Rutherford |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Lidocaine
Lingual artery medicine.drug_class Femoral artery Models Biological Cerebral circulation medicine.artery medicine Animals Brachial artery Vein Local anesthetic business.industry Arteries Haplorhini Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Blood Circulation cardiovascular system Internal carotid artery business Anesthesia Local Papio medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 57:428 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/00000539-197807000-00011 |
| Popis: | In baboons, lidocaine HCl was injected into the lingual (3 mg/kg), brachial (7 mg/kg), or femoral (7 mg/kg) arteries. Blood samples were taken from the internal carotid artery (ICA), internal jugular (IJV), external jugular (EJV), brachial (BV), or femoral (FV) vein, depending on the injection site, 6, 30, and 180 seconds after injection. Subsequently, radioactive microspheres (20 micron in diameter) were injected into the lingual artery, and the brains were obtained 48 hours later at postmortem to locate the microspheres. Six seconds after injection into the lingual artery, lidocaine concentration in ICA was 28 microgram/ml, whereas peak levels in IJV and EJV occurred at 30 seconds, being 51 and 25.7 microgram/ml, respectively. After injection into the brachial artery, peak average ICA levels were 105.5 microgram/ml at 6 seconds, while only 20.6 microgram/ml concentration was noted in ICA after injection into the femoral artery. Seventy-four precent of the Sr90 labeled microspheres were found lodged in the ipsilateral cerebral hemisphere. Local anesthetic drugs accidentally injected into arteries may reach the cerebral circulation following a centripetal pathway and thus produce central nervous system toxic responses. |
| Databáze: | OpenAIRE |
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