Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control

Autor: David J. Lythgoe, Jilly Naaijen, Esther Aarts, Catharina A. Hartman, Marcel P. Zwiers, Pieter J. Hoekstra, Jan K. Buitelaar
Přispěvatelé: Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Magnetic Resonance Spectroscopy
Image Processing
Magnetic Resonance Imaging/methods
0302 clinical medicine
Neurodevelopmental disorder
Computer-Assisted
Oxygen/blood
Image Processing
Computer-Assisted
Pharmacology (medical)
Child
Correlation of Data
medicine.diagnostic_test
Glutamate receptor
220 Statistical Imaging Neuroscience
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
Schizophrenia
Glutamic Acid/metabolism
Female
medicine.symptom
Protons
psychological phenomena and processes
Adult
medicine.medical_specialty
Adolescent
Glutamic Acid
Impulsivity
Gyrus Cinguli
behavioral disciplines and activities
150 000 MR Techniques in Brain Function
Cognition Disorders/diagnostic imaging
03 medical and health sciences
Young Adult
All institutes and research themes of the Radboud University Medical Center
Attention Deficit Disorder with Hyperactivity/complications
Internal medicine
medicine
Attention deficit hyperactivity disorder
Humans
Biological Psychiatry
Anterior cingulate cortex
Pharmacology
Analysis of Variance
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Gyrus Cinguli/diagnostic imaging
business.industry
medicine.disease
Corpus Striatum
Oxygen
030104 developmental biology
Endocrinology
nervous system
Attention Deficit Disorder with Hyperactivity
Corpus Striatum/diagnostic imaging
Neurology (clinical)
Cognition Disorders
Functional magnetic resonance imaging
business
170 000 Motivational & Cognitive Control
030217 neurology & neurosurgery
Stroop effect
Zdroj: European Neuropsychopharmacology, 28, 381-391
European Neuropsychopharmacology, 28, 3, pp. 381-391
European Neuropsychopharmacology, 28(3), 381-391. ELSEVIER SCIENCE BV
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2018.01.002
Popis: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by structural, functional and neurochemical alterations of the fronto-striatal circuits and by deficits in cognitive control. In particular, ADHD has been associated with impairments in top-down fronto-striatal glutamate-signalling. However, it is unknown whether fronto-striatal glutamate is related to cognitive control dysfunction. Here we explored whether and how anterior cingulate cortex (ACC) glutamate relates to striatal BOLD-responses during cognitive control. We used proton magnetic resonance spectroscopy to evaluate glutamate-to-creatine ratios in 62 participants (probands with ADHD n=19, unaffected siblings n=24 and typical controls n=19, mean age=20.4). Spectra were collected from the ACC and the dorsal striatum and glutamate-to-creatine ratios were extracted. Thirty-two participants additionally took part in a functional magnetic resonance imaging (fMRI) Stroop task to investigate neural responses during cognitive control. Given small sample sizes we report all effects with p
Databáze: OpenAIRE
Externí odkaz: