Role of stem cell-derived exosomes in cancer
| Autor: | Junyi Wu, Junhua Wu, Zhen Qu, Chun‑Ping Jiang, Zi‑Wei Fei |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research cancer stem cell Cell Population Review exosomes Biology 03 medical and health sciences angiogenesis 0302 clinical medicine Cancer stem cell medicine metastasis education mesenchymal stem cell education.field_of_study Tumor microenvironment therapy Mesenchymal stem cell multivesicular bodies Microvesicles Cell biology stem cell 030104 developmental biology medicine.anatomical_structure tumor growth Oncology Cell culture 030220 oncology & carcinogenesis Immunology biomarker Stem cell extracellular vesicles |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | Exosomes are small, extracellular membrane- enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, secrete exosomes into the extracellular environment, and are significant communicators in the tumor microenvironment. Stem cells are a unique cell population defined by their ability to indefinitely self-renew, differentiate into a variety of cell lines, and form clonal cell populations. Stem cells also secrete large amounts of exosomes, which have demonstrated great potential in a variety of diseases. Increasing evidence has revealed that the mechanism of interaction between stem cells and human tumor cells involves the exchange of biological material through exosomes. In this review, the latest developments in the role of stem cell-derived exosomes in cancer are highlighted. |
| Databáze: | OpenAIRE |
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