Movement-generated afference paired with transcranial magnetic stimulation: an associative stimulation paradigm
| Autor: | Ana H. Medeiros, Francis Mastaglia, Asli Demirtas-Tatlidede, Laura Dipietro, Alvaro Pascual-Leone, Dylan J. Edwards, Hermano Igo Krebs, Gary W. Thickbroom |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Mechanical Engineering, Dipietro, Laura, Krebs, Hermano Igo |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Movement Stimulation Health Informatics Electromyography Audiology Somatosensory system 050105 experimental psychology 03 medical and health sciences Young Adult 0302 clinical medicine Movement associative stimulation medicine Humans 0501 psychology and cognitive sciences Evoked potential Motor evoked potential Passive movement Cross-Over Studies medicine.diagnostic_test Research 05 social sciences Rehabilitation Motor Cortex Repeated measures design Middle Aged Evoked Potentials Motor Transcranial Magnetic Stimulation 3. Good health Transcranial magnetic stimulation medicine.anatomical_structure Female Primary motor cortex Psychology Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | BioMed Central Ltd Journal of NeuroEngineering and Rehabilitation |
| Popis: | Background: A peripheral nerve stimulus can enhance or suppress the evoked response to transcranial magnetic stimulation (TMS) depending on the latency of the preceding peripheral nerve stimulation (PNS) pulse. Similarly, somatosensory afference from the passively moving limb can transiently alter corticomotor excitability, in a phase-dependent manner. The repeated association of PNS with TMS is known to modulate corticomotor excitability; however, it is unknown whether repeated passive-movement associative stimulation (MAS) has similar effects. Methods: In a proof-of-principle study, using a cross-over design, seven healthy subjects received in separate sessions: (1) TMS (120% of the resting motor threshold-RMT, optimal site for Flexor Carpi Radialis) with muscle at rest; (2) TMS paired with cyclic passive movement during extension cyclic passive movement (400 pairs, 1 Hz), with the intervention order randomly assigned. Normality was tested using the Kolmogorov-Smirnov test, then compared to pre-intervention baseline using repeated measures ANOVA with a Dunnet multiple comparisons test. Results: MAS led to a progressive and significant decrease in the motor evoked potential (MEP) amplitude over the intervention (R[superscript 2] = 0.6665, P < 0.0001), which was not evident with TMS alone (R[superscript 2] = 0.0068, P = 0.641). Post-intervention excitability reduction, only present with MAS intervention, remained for 20min (0-10min 68.2 ± 4.9%, P < 0.05; 10-20min = 73.3 ± 9.7%, P < 0.05). Conclusion: The association of somatosensory afference from the moving limb with TMS over primary motor cortex in healthy subjects can be used to modulate corticomotor excitability, and may have therapeutic implications. National Institutes of Health (U.S.) (Grant RO1 HD045343) |
| Databáze: | OpenAIRE |
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