Alterations of CSF Cystatin C Levels and Their Correlations with CSF Αβ40 and Αβ42 Levels in Patients with Alzheimer's Disease, Dementia with Lewy Bodies and the Atrophic Form of General Paresis

Autor: Nan Mu, Guo-Yan Hu, Xue-Jun Liu, Yan Tan, Yuping Ning, Yue-Feng Zhang, Xinni Luo, Dong Zheng, Jian-Ping Chen, Le Hou, Hongbo He, Haishan Shi, Xiaomei Zhong, Xinru Chen
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE
PLoS ONE, Vol 8, Iss 1, p e55328 (2013)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0055328
Popis: Immunohistochemical studies have revealed that cystatin C (CysC) co-localizes with amyloid-β (Αβ) in amyloid-laden vascular walls and in the senile plaque cores of amyloid. In vitro and in vivo animal studies suggest that CysC protects against neurodegeneration by inhibition of cysteine proteases, inhibition of Αβ aggregation, induction of autophagy and induction of cell division. CysC levels may be altered and may have a potential link with cerebrospinal fluid (CSF) Aβ levels in various types of dementia with characteristic amyloid deposits, such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and the atrophic form of general paresis (AF-GP). We assessed the serum and CSF levels of CysC and the CSF levels of Aβ40 and Aβ42 in patients with AD (n = 51), DLB (n = 26) and AF-GP (n = 43) and normal controls (n = 30). Using these samples, we explored the correlation between CSF CysC and CSF Aβ levels. We found that in comparison to the normal control group, both CSF CysC and CSF Aβ42 levels were significantly lower in all three dementia groups (all p
Databáze: OpenAIRE