Alterations of CSF Cystatin C Levels and Their Correlations with CSF Αβ40 and Αβ42 Levels in Patients with Alzheimer's Disease, Dementia with Lewy Bodies and the Atrophic Form of General Paresis
| Autor: | Nan Mu, Guo-Yan Hu, Xue-Jun Liu, Yan Tan, Yuping Ning, Yue-Feng Zhang, Xinni Luo, Dong Zheng, Jian-Ping Chen, Le Hou, Hongbo He, Haishan Shi, Xiaomei Zhong, Xinru Chen |
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| Rok vydání: | 2013 |
| Předmět: |
Lewy Body Disease
Pathology medicine.medical_specialty Amyloid Dementia with Lewy bodies lcsh:Medicine Biochemistry Statistics Nonparametric Cerebrospinal fluid Diagnostic Medicine Alzheimer Disease Neurosyphilis mental disorders medicine Humans Dementia Senile plaques Cystatin C lcsh:Science Biology Psychiatry Amyloid beta-Peptides Multidisciplinary biology business.industry lcsh:R Neurodegeneration Proteins Creatine medicine.disease Immunohistochemistry Peptide Fragments Mental Health Neurology biology.protein Medicine lcsh:Q Alzheimer's disease business Biomarkers Research Article General Pathology Glomerular Filtration Rate |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e55328 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Immunohistochemical studies have revealed that cystatin C (CysC) co-localizes with amyloid-β (Αβ) in amyloid-laden vascular walls and in the senile plaque cores of amyloid. In vitro and in vivo animal studies suggest that CysC protects against neurodegeneration by inhibition of cysteine proteases, inhibition of Αβ aggregation, induction of autophagy and induction of cell division. CysC levels may be altered and may have a potential link with cerebrospinal fluid (CSF) Aβ levels in various types of dementia with characteristic amyloid deposits, such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and the atrophic form of general paresis (AF-GP). We assessed the serum and CSF levels of CysC and the CSF levels of Aβ40 and Aβ42 in patients with AD (n = 51), DLB (n = 26) and AF-GP (n = 43) and normal controls (n = 30). Using these samples, we explored the correlation between CSF CysC and CSF Aβ levels. We found that in comparison to the normal control group, both CSF CysC and CSF Aβ42 levels were significantly lower in all three dementia groups (all p |
| Databáze: | OpenAIRE |
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