Pentobarbital therapy for status epilepticus in children: timing of tapering
| Autor: | Kenji Sugai, Eiji Nakagawa, Shigeru Hanaoka, Yuji Iwasaki, Hirotoshi Kinoshita |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Phenytoin
Male Pentobarbital Lidocaine medicine.medical_treatment Status epilepticus Drug Administration Schedule Epilepsy Status Epilepticus Developmental Neuroscience medicine Humans Child Evoked Potentials Monitoring Physiologic Mechanical ventilation Dose-Response Relationship Drug business.industry Electroencephalography medicine.disease Anticonvulsant Neurology Anesthesia Child Preschool Pediatrics Perinatology and Child Health Anticonvulsants Drug Therapy Combination Female Neurology (clinical) medicine.symptom business Diazepam medicine.drug |
| Zdroj: | Pediatric neurology. 13(2) |
| ISSN: | 0887-8994 |
| Popis: | Three children with refractory status epilepticus, unresponsive to intravenous administration of diazepam, phenytoin, and lidocaine, received pentobarbital therapy and were monitored by electroencephalography (EEG). They required mechanical ventilation and vasopressor therapy. Intravenous pentobarbital therapy was successful and without distinct sequelae in all 3 patients, and could be incrementally discontinued without breakthrough seizures after 12-65 hours of a burst-suppression or complete suppression pattern on EEG. Obtaining a suppression pattern was important for controlling status epilepticus in children as well as adults. We suggest that 12 hours after a burst-suppression pattern is obtained, tapering of pentobarbital should be attempted to avoid serious complications of extended pentobarbital anesthesia (e.g., respiratory depression, hypotension, pneumonia). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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