Apoptosis restores cellular density by eliminating a physiologically or genetically induced excess of enterocytes in the Drosophila midgut
| Autor: | Marie-Paule Nawrot-Esposito, Armel Gallet, Olivia Benguettat, David Pauron, Marcel Amichot, Alexandra Brun-Barale, Rihab Loudhaief |
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| Přispěvatelé: | Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Institute of Developmental Biology and Cancer (IBDC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), ANR-13-CESA-0003-01, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell signaling cell killing Cellular differentiation régénération cellulaire Cellular homeostasis Apoptosis Biology Opportunistic bacteria entérocyte fonction intestinale épithélium intestinal 03 medical and health sciences 0302 clinical medicine intestinal epithelium renouvellement cellulaire Molecular Biology [SDV.BDD]Life Sciences [q-bio]/Development Biology activité cellulaire JNK signaling apoptose mort cellulaire Hippo signaling drosophila Intestinal epithelium Cell biology Gut Epithelium 030104 developmental biology Cell killing Drosophila intestine Immunology Stem cell vinegar flies [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery pathogen agent pathogène Developmental Biology |
| Zdroj: | Development (Cambridge, England) Development (Cambridge, England), Company of Biologists, 2017, 144 (5), pp.808-819. ⟨10.1242/dev.142539⟩ |
| ISSN: | 1477-9129 0950-1991 |
| Popis: | International audience; Using pathogens or high levels of opportunistic bacteria to damage the gut, studies in Drosophila have identified many signaling pathways involved in gut regeneration. Dying cells emit signaling molecules that accelerate intestinal stem cell proliferation and progenitor differentiation to replace the dying cells quickly. This process has been named 'regenerative cell death'. Here, mimicking environmental conditions, we show that the ingestion of low levels of opportunistic bacteria was sufficient to launch an accelerated cellular renewal program despite the brief passage of bacteria in the gut and the absence of cell death and this is is due to the moderate induction of the JNK pathway that stimulates stem cell proliferation. Consequently, the addition of new differentiated cells to the gut epithelium, without preceding cell loss, leads to enterocyte overcrowding. Finally, we show that a couple of days later, the correct density of enterocytes is promptly restored by means of a wave of apoptosis involving Hippo signaling and preferential removal of old enterocytes. |
| Databáze: | OpenAIRE |
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