Listeria monocytogenes-associated respiratory infections: a study of 38 consecutive cases
| Autor: | M. Morgand, Mylène M. Maury, Caroline Charlier, Alexandre Leclercq, Pierre Thouvenot, Guillaume Vales, Hélène Bracq-Dieye, Marc Lecuit |
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| Přispěvatelé: | Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de Référence Listeria - National Reference Center Listeria (CNRL), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Institut Pasteur [Paris]-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Biologie des Infections - Biology of Infection, Université Paris Descartes - Paris 5 (UPD5), Funding was received from the Institut Pasteur, Santé Publique, France., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), DIAKITE, andrée |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Lung Diseases
Male 0301 basic medicine MESH: Respiratory Tract Infections/epidemiology MESH: Listeria monocytogenes/isolation & purification MESH: Empyema Pleural/microbiology Pleural effusion MESH: Empyema Pleural/etiology medicine.medical_treatment [SDV]Life Sciences [q-bio] MESH: Empyema Pleural/drug therapy MESH: Listeriosis/epidemiology MESH: Listeriosis/drug therapy MESH: Aged 80 and over listeriosis pleural effusion [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Sepsis/etiology MESH: Anti-Bacterial Agents/therapeutic use Respiratory Tract Infections MESH: Respiratory Tract Infections/etiology Aged 80 and over MESH: Aged Pleuropneumonia [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology MESH: Middle Aged Respiratory infection Immunosuppression General Medicine Middle Aged MESH: Pneumonia Bacterial/drug therapy MESH: Pneumonia Bacterial/etiology MESH: Sepsis/epidemiology Anti-Bacterial Agents 3. Good health [SDV] Life Sciences [q-bio] Infectious Diseases medicine.anatomical_structure [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology MESH: Lung Diseases/microbiology [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Pneumonia Bacterial/microbiology Female MESH: Empyema Pleural/epidemiology medicine.drug Adult Microbiology (medical) MESH: Pleuropneumonia/microbiology MESH: Pneumonia Bacterial/epidemiology MESH: Lung Diseases/epidemiology medicine.medical_specialty 030106 microbiology MESH: Pleuropneumonia/drug therapy 03 medical and health sciences MESH: Listeriosis/complications Sepsis Internal medicine Pneumonia Bacterial medicine Humans pneumonia MESH: Sepsis/drug therapy MESH: Lung Diseases/drug therapy [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology MESH: Respiratory Tract Infections/drug therapy Empyema Pleural Aged Retrospective Studies MESH: Pleuropneumonia/etiology MESH: Sepsis/microbiology Lung MESH: Humans business.industry MESH: Respiratory Tract Infections/microbiology MESH: Adult MESH: Retrospective Studies Amoxicillin medicine.disease Listeria monocytogenes [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Empyema MESH: Male Pneumonia MESH: Lung Diseases/etiology Concomitant MESH: Listeriosis/microbiology MESH: Listeria monocytogenes/drug effects MESH: Pleuropneumonia/epidemiology [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology business MESH: Female [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Clinical Microbiology and Infection Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2018, 24 (12), pp.1339.e1-1339.e5. ⟨10.1016/j.cmi.2018.03.003⟩ Clinical Microbiology and Infection, 2018, 24 (12), pp.1339.e1-1339.e5. ⟨10.1016/j.cmi.2018.03.003⟩ |
| ISSN: | 1198-743X 1469-0691 |
| Popis: | Listeria monocytogenes (Lm) is a foodborne human pathogen responsible for severe infections, including septicaemia, neurolisteriosis, and maternal-foetal and focal infections. Little is known about Lm-associated respiratory tract or lung infections.We conducted a retrospective study of culture-proven cases of Lm pleural infections and pneumonia reported to the French National Reference Centre for Listeria from January 1993 to August 2016.Thirty-eight consecutive patients with pleural infection (n = 32), pneumonia (n = 5), or both (n = 1) were studied; 71% of these were men. Median age was 72 (range 29-90). Two patients presented with concomitant neurolisteriosis. All patients but one reported at least one immunosuppressive condition (97%), with a median number of 2 (range 0-5), including 29% (8/28) with current exposure to immunosuppressive therapy and 50% (17/34) with ongoing neoplasia; 75% (21/28) reported previous pleural or pulmonary disease. Antibiotic therapy mostly consisted in amoxicillin (72%) associated with aminoglycoside in 32%. Chest-tube drainage was performed in 7/19 patients with empyema (37%); 25% of the patients (7/30) required intensive care management. In-hospital mortality reached 35% and occurred after a median time interval of 4 days (range 1-33 days). Three patients had recurrence of empyema (time interval of 1 week to 4 months after treatment completion). Altogether, only 13/31 patients (42%) diagnosed with Lm respiratory infection experienced an uneventful outcome at 2-year follow-up.Lm is a rare but severe cause of pneumonia and pleural infection in older immunocompromised patients, requiring prompt diagnosis and adequate management and follow-up. |
| Databáze: | OpenAIRE |
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