The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats
| Autor: | Xuan-xuan Zhu, Ming Zhang, Yiwen Zheng, Shweta Vagal, Paul F. Smith, Cynthia L. Darlington, Guangji Wang, Catherine de Waele |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Complementary Therapies
Male Pueraria Schisandra chinensis Herbal Medicine Conditioning Classical Traditional Chinese medicine Salvia Pharmacology Tinnitus Drug Discovery Post-hoc analysis otorhinolaryngologic diseases medicine Animals Medicine Chinese Traditional Rats Wistar biology Traditional medicine business.industry Cornus officinalis biology.organism_classification Rehmannia glutinosa Salicylates Rats medicine.symptom business Drugs Chinese Herbal |
| Zdroj: | Journal of Ethnopharmacology. 128:545-548 |
| ISSN: | 0378-8741 |
| Popis: | Aim of the study Traditional Chinese medicine (TCM) has been reported to successfully alleviate tinnitus, although well-controlled studies have not been conducted. In this study, we attempted to test a TCM, Er Ming Fang (EMF01) containing Rehmannia glutinosa , Cornus officinalis , Salvia mittiorrhiza , Pueraria , Schisandra chinensis , Poria cocos and Platycodon grandiflorum , on salicylate-induced tinnitus in rats, using a conditioned lick suppression paradigm. Materials and methods A pilot study examined the effect of 8.75 g/kg and 17.5 g/kg EMF01 (delivered by oral gavage for 20 days) and showed a slight decrease in the suppression ratio (SR) in the 8.75 g/kg group. In order to confirm the possible effect of EMF01 on tinnitus at 8.75 g/kg, a further study was carried out with a larger sample size. Results While there were statistically significant differences between the treatment groups, post hoc tests revealed that EMF01 did not have any significant effect on salicylate-induced tinnitus. Conclusions While this study does not support the efficacy of EMF01 in the treatment of salicylate-induced tinnitus, further studies should be conducted to determine if it alleviates tinnitus associated with acoustic trauma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect