Biogenic Silver Nanoparticles of Clinacanthus nutans as Antioxidant with Antimicrobial and Cytotoxic Effects

Autor:	Nik Nur Syazni Nik Mohamed Kamal, Muggundha Raoov Ramachandran, Wai Hau Tung, Nur Nadhirah Mohamad Zain, Vuanghao Lim, Noorfatimah Yahaya, Che Nurul Azieyan Che Mood, Yoke Keong Yong, Hock Ing Chiu, Chee Keong Lee
Rok vydání:	2021
Předmět:	Antioxidant Article Subject DPPH medicine.medical_treatment ved/biology.organism_classification_rank.species 02 engineering and technology Biochemistry Clinacanthus nutans Silver nanoparticle Inorganic Chemistry HeLa 03 medical and health sciences chemistry.chemical_compound medicine Cytotoxicity QD146-197 030304 developmental biology 0303 health sciences ABTS biology ved/biology Organic Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial chemistry 0210 nano-technology TP248.13-248.65 Biotechnology Nuclear chemistry
Zdroj:	Bioinorganic Chemistry and Applications, Vol 2021 (2021)
ISSN:	1687-479X 1565-3633
DOI:	10.1155/2021/9920890
Popis:	Silver nanoparticles (AgNPs) previously synthesised using leaf (AgNP-L) and stem (AgNP-S) extracts of Clinacanthus nutans (C. nutans) were tested to evaluate antimicrobial, antioxidant, and cytotoxicity activities. The AgNPs showed good inhibition against bacteria, but not fungi. The inhibition results showed the highest activity against Staphylococcus aureus (S. aureus) with 11.35 mm (AgNP-L) and 11.52 mm (AgNP-S), while the lowest inhibition was against Escherichia coli (E. coli) with 9.22 mm (AgNP-L) and 9.25 mm (AgNP-S) in the disc diffusion method. The same trend of results was noted in the well diffusion method. The IC50 of AgNP-L and AgNP-S in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays was 417.05 μg/mL and 434.60 μg/mL, as well as 304.31 μg/mL and 326.83 μg/mL, respectively. Ferric reducing power (FRAP) assay showed that AgNP-L [872.389 μmol/L Fe(II)] and AgNP-S [612.770 μmol/L Fe(II)] exhibited significantly ( p p
Databáze:	OpenAIRE
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