Novel benzimidazole derivatives as selective CB2 agonists

Autor:	Daniel, Pagé, Elise, Balaux, Luc, Boisvert, Ziping, Liu, Claire, Milburn, Maxime, Tremblay, Zhongyong, Wei, Simon, Woo, Xuehong, Luo, Yun-Xing, Cheng, Hua, Yang, Sanjay, Srivastava, Fei, Zhou, William, Brown, Miroslaw, Tomaszewski, Christopher, Walpole, Leila, Hodzic, Stéphane, St-Onge, Claude, Godbout, Dominic, Salois, Kemal, Payza, Keymal, Payza
Rok vydání:	2008
Předmět:	Agonist Benzimidazole Cannabinoid receptor medicine.drug_class Stereochemistry Chemistry Pharmaceutical Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Binding Competitive Receptor Cannabinoid CB2 chemistry.chemical_compound Structure-Activity Relationship Receptor Cannabinoid CB1 Drug Discovery Cannabinoid Receptor Modulators Cannabinoid receptor type 2 medicine Moiety Humans Technology Pharmaceutical Receptors Cannabinoid Molecular Biology Bicyclic molecule Chemistry Cannabinoids Organic Chemistry Models Chemical Drug Design Molecular Medicine lipids (amino acids peptides and proteins) Benzimidazoles Selectivity
Zdroj:	Bioorganicmedicinal chemistry letters. 18(13)
ISSN:	1464-3405
Popis:	The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38faeba6c5ce18da2d54a009c6fb34 https://pubmed.ncbi.nlm.nih.gov/18522867 Zobrazit plný text záznamu Full Text from ScienceDirect