The relationship between famine exposure during early life and body mass index in adulthood: A systematic review and meta-analysis

Autor: Guo-Xiu Wang, Jielin Zhou, Liang-Jian Zhang, Qing-Li Bo, Yong Fan, Sufang Wang, Chun-Qiu Hu, Peng Xuan, Linsheng Yang, Jie Sheng
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Physiology
lcsh:Medicine
Overweight
Body Mass Index
Geographical Locations
0302 clinical medicine
Mathematical and Statistical Techniques
Medicine and Health Sciences
030212 general & internal medicine
lcsh:Science
Multidisciplinary
Research Assessment
Middle Aged
Europe
Physiological Parameters
Meta-analysis
Physical Sciences
Famine
Female
medicine.symptom
Statistics (Mathematics)
Research Article
Adult
Childhood Obesity
Asia
Systematic Reviews
Natural Disasters
030209 endocrinology & metabolism
Research and Analysis Methods
Childhood obesity
03 medical and health sciences
medicine
Humans
Obesity
Statistical Methods
business.industry
lcsh:R
Body Weight
Biology and Life Sciences
Odds ratio
medicine.disease
Starvation
Relative risk
People and Places
Earth Sciences
lcsh:Q
business
Body mass index
Mathematics
Demography
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192212 (2018)
ISSN: 1932-6203
Popis: Background Previous epidemiologic studies have reported famine exposure during early life association with overweight or obesity in adulthood, but a consistent perspective has not been established to date. Purpose To determine, by conducting a systematic review and meta-analysis, whether exposure to famine could increase body mass index (BMI) in adult or not, and assess the association between famine exposure and the risk of overweight or obesity. Methods Published articles were systematically searched (until August, 2017) from PubMed, ScienceDirect, Cochrane, and China National Knowledge Infrastructure. Initially, comparing differences in BMI between exposed and non-exposed groups that weight mean difference (WMD) were used. Subsequently, the effect of famine exposure on overweight or obesity risk, which pooled relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Result Twenty studies were included in this systematic review and meta-analysis. Compared with non-exposed group, famine exposure group significantly increased the risk of overweight (OR = 1.10, 95% CI: 1.04–1.16) and obesity (OR = 1.15, 95% CI: 1.05–1.24). Sensitivity analyses revealed no significant change in the famine exposure and BMI, the risk of overweight and obesity study when any one study was excluded. Subgroup analyses showed that age, gender, exposure type, study type, continent, famine cause and paper publication date were associated with BMI, the risk of overweight and obesity. Meta-regression analyses suggested that continent, famine cause could partially explain heterogeneity for famine exposure and BMI studies. Conclusion The systematic review and meta-analysis indicates that famine exposure during early life may increase BMI, the risk of overweight and obesity, especially for female, fetal famine exposure or subject age less than 50. Furthermore, famine exposure group the risk of overweight and obesity in cross-sectional studies, Asian studies, famine cause by natural disaster or paper published from 2015 to the present studies are higher than that of non-exposed group.
Databáze: OpenAIRE
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