Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism
| Autor: | J. Christopher Eagon, Faidon Magkos, David Bradley, Olga Ilkayeva, Christopher B. Newgard, Samuel Klein, Brian N. Finck, George G. Schweitzer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Gastroplasty Endocrinology Diabetes and Metabolism medicine.medical_treatment Branched-chain amino acid Calorie restriction Gastric Bypass 030209 endocrinology & metabolism Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Weight loss Internal medicine Internal Medicine medicine Glucose homeostasis Humans Insulin Obesity Phosphorylation Muscle Skeletal PI3K/AKT/mTOR pathway 030304 developmental biology Original Research Caloric Restriction 0303 health sciences TOR Serine-Threonine Kinases Metabolism medicine.disease Endocrinology chemistry Female Laparoscopy medicine.symptom Insulin Resistance Amino Acids Branched-Chain |
| Zdroj: | Diabetes |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | It has been hypothesized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glucose homeostasis, possibly by decreased signaling through the mammalian target of rapamycin (mTOR). We evaluated plasma BCAAs and their C3 and C5 acylcarnitine metabolites, muscle mTOR phosphorylation, and insulin sensitivity (insulin-stimulated glucose Rd) in obese subjects before and after ∼20% weight loss induced by RYGB (n = 10, BMI 45.6 ± 6.7 kg/m2) or laparoscopic adjustable gastric banding (LAGB) (n = 10, BMI 46.5 ± 8.8 kg/m2). Weight loss increased insulin-stimulated glucose Rd by ∼55%, decreased total plasma BCAA and C3 and C5 acylcarnitine concentrations by 20–35%, and did not alter mTOR phosphorylation; no differences were detected between surgical groups (all P values for interaction >0.05). Insulin-stimulated glucose Rd correlated negatively with plasma BCAAs and with C3 and C5 acylcarnitine concentrations (r values −0.56 to −0.75, P < 0.05). These data demonstrate that weight loss induced by either LAGB or RYGB causes the same decline in circulating BCAAs and their C3 and C5 acylcarnitine metabolites. Plasma BCAA concentration is negatively associated with skeletal muscle insulin sensitivity, but the mechanism(s) responsible for this relationship is not known. |
| Databáze: | OpenAIRE |
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