A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Autor:	Ryan K. Mitchell, Natalie R. Johnston, Johannes Broichhagen, K. Šmid, James A. Frank, Dirk Trauner, David J. Hodson, Piero Marchetti, Marco Bugliani, Guy A. Rutter
Rok vydání:	2015
Předmět:	Materials Chemistry2506 Metals and Alloys Light Animals Azo Compounds Calcium Cells Cultured Diazoxide Gene Expression Regulation Guanine Nucleotide Exchange Factors HEK293 Cells Humans Hypoglycemic Agents Insulin Insulin-Secreting Cells Islets of Langerhans Mice Photochemical Processes Potassium Signal Transduction Sulfonylurea Compounds Sulfonylurea Receptors Chemistry (all) Catalysis Ceramics and Composites Electronic Optical and Magnetic Materials Surfaces Coatings and Films 2506 Medicine (all) Coatings and Films chemistry.chemical_compound Insulin Secretion Materials Chemistry Cultured Metals and Alloys 3. Good health Surfaces Biochemistry Azobenzene medicine.drug_class Cells Beta-cell Function Article Photochromism medicine Electronic Optical and Magnetic Materials General Chemistry Sulfonylurea Optical control chemistry Biophysics
Zdroj:	Chemical communications (Cambridge, England). 51(27)
ISSN:	1364-548X
Popis:	Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push–pull system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30ee464edfe1aac502a4ff91786d62 https://pubmed.ncbi.nlm.nih.gov/25744824 Zobrazit plný text záznamu