Incidental Coronary Artery Calcification Seen on Low-Dose Computed Tomography Is a Risk Factor for Obstructive Coronary Artery Disease in Patients Undergoing Liver Transplant
| Autor: | David M. Shavelle, J.S. Bainiwal, Newton Phuong, Naga L. Dharmavaram, W.S. Schwartzman, Parveen K. Garg, Peter Xu, Jeffrey Kahn, A.N. Baffo, H.M. Van Herle, Han Tun, Andrew J. Yoon, Brian Butera, B. Yasmeh, Brian S. Kim, Emily Andersen, Nina Gertsvolf, T. Othman |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Coronary Artery Disease Coronary Angiography Coronary artery disease Risk Factors Internal medicine Odds Ratio medicine Humans In patient Risk factor Aged Retrospective Studies Transplantation business.industry Calcinosis Retrospective cohort study Odds ratio Middle Aged medicine.disease Liver Transplantation Peripheral Arterial calcification medicine.anatomical_structure Cardiology Female Surgery Tomography X-Ray Computed business Artery |
| Zdroj: | Transplantation Proceedings. 50:3487-3495 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2018.11.001 |
| Popis: | Incidental arterial calcification (Ca) on low-dose computed tomography (CT) prior to liver transplant (LT) may help identify those at risk for obstructive coronary artery disease (CAD). A single-center retrospective study of 358 consecutive patients who had undergone LT was performed. Of the 296 patients who met inclusion criteria, 193 patients (65.2%) had CT Ca. Aortic Ca was seen in 116 (39.2%), coronary Ca in 141 (47.6%), and peripheral Ca in 8 patients (2.7%). Patients with coronary Ca were assigned ordinal coronary artery Ca scores and classified as mild, moderate, and severe. All-cause mortality was higher in patients with Ca in any location (14.5% vs 6.8%, P = .05). Of the patients who underwent coronary angiography, those with obstructive CAD were more likely to have aortic and coronary Ca than patients with nonobstructive or no CAD (85.7% vs 50.0%, P = .02 and 92.9% vs 37.9%, P = < .001, respectively). Severe coronary artery Ca scores were more frequent in patients with obstructive CAD (35.7% vs 0%, P < .001). Any severity coronary Ca had an odds ratio of 11.57 (95% CI, 1.61-244.92; P = .04) for obstructive CAD. In conclusion, incidental coronary Ca seen on low-dose CT is a risk factor for obstructive CAD in patients undergoing LT. |
| Databáze: | OpenAIRE |
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