A Systematic Review of Animal Models of NAFLD Finds High‐Fat, High‐Fructose Diets Most Closely Resemble Human NAFLD
| Autor: | Yu Ri Im, Hong Kai Lim, Qinrong Cheah, Harriet Hunter, Jiawen Dong, Mrudula Utukuri, Dana de Gracia Hahn, Jake P. Mann, Ian A. Rowe, Amedine Duret, Alice Li, Lorcan McKeown, Madison Fairey, Clarissa Hjalmarsson, Raunak Rao, Claudia Gabriela Mitrofan |
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| Přispěvatelé: | Rowe, Ian A. [0000-0003-1288-0749], Mann, Jake P. [0000-0002-4711-9215], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Dietary Sugars Fructose Computational biology Biology Diet High-Fat High fat high fructose Animals Genetically Modified Cholesterol Dietary Mice 03 medical and health sciences 0302 clinical medicine Human disease Dietary Sucrose Non-alcoholic Fatty Liver Disease Internal medicine Genetic model medicine Animals Humans Obesity Human phenotype Dyslipidemias Metabolic Syndrome Hepatology Clinical study design Reproducibility of Results Original Articles digestive system diseases Diet Rats Disease Models Animal 030104 developmental biology Liver Original Article Female 030211 gastroenterology & hepatology |
| Zdroj: | Hepatology. 74:1884-1901 |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | Background and aims Animal models of human disease are a key component of translational hepatology research, yet there is no consensus on which model is optimal for NAFLD. Approach and results We generated a database of 3,920 rodent models of NAFLD. Study designs were highly heterogeneous, and therefore, few models had been cited more than once. Analysis of genetic models supported the current evidence for the role of adipose dysfunction and suggested a role for innate immunity in the progression of NAFLD. We identified that high-fat, high-fructose diets most closely recapitulate the human phenotype of NAFLD. There was substantial variability in the nomenclature of animal models: a consensus on terminology of specialist diets is needed. More broadly, this analysis demonstrates the variability in preclinical study design, which has wider implications for the reproducibility of in vivo experiments both in the field of hepatology and beyond. Conclusions This systematic analysis provides a framework for phenotypic assessment of NAFLD models and highlights the need for increased standardization and replication. |
| Databáze: | OpenAIRE |
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