Validation of MRI Measurement of Cardiac Output in the Dog: The Effects of Dobutamine and Minoxidil
| Autor: | Mark R Slaughter, Bela Rajiv Patel, Heather L. Lloyd, Greg Whelan, Janette A. Osborne, Joanne Byrne, David Templeton, Karen Pointing, David G. Reid, Alan White, Albert L. Busza, Belinda A. Farnfield, Gemma L. Taylor, Paul D. Hockings, Sean C. Smart, Jeffrey M. Birmingham, Ana Criado-Gonzalez, Axel Krebs-Brown |
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| Rok vydání: | 2003 |
| Předmět: |
Inotrope
medicine.medical_specialty Cardiac output medicine.diagnostic_test business.industry Health Toxicology and Mutagenesis Diastole Magnetic resonance imaging Stroke volume Toxicology medicine.disease Pericardial effusion Internal medicine medicine Cardiology Dobutamine Multislice business medicine.drug |
| Zdroj: | Toxicology Mechanisms and Methods. 13:39-43 |
| ISSN: | 1537-6524 1537-6516 |
| Popis: | The use of magnetic resonance imaging (MRI) for the measurement of cardiac output parameters in anesthetized adult male beagle dogs has been validated against a widely accepted thermodilution method. Using a multislice cine gradient echo MRI method to acquire images of the entire heart, left ventricular lumen volumes were measured at systole and diastole in seven animals. Cardiac output correlated well (R 2 = 0.88) with thermodilution measurements made in a parallel manner, both before and during acute stimulation with the inotrope dobutamine. In a chronic study of changes in cardiac morphology and function brought about by the antihypertensive minoxidil, MRI reliably detected the expected increases in stroke volume (28%) and cardiac output (58%) resulting from neural reaction to decreased blood pressure. Left ventricular lumen enlarged as well in response to fluid retention and plasma volume increase. Two in four minoxidil-treated animals also developed clear MRI-visible pericardial effusion. |
| Databáze: | OpenAIRE |
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