Ghrelin concentration as an indicator of eating-disorder risk in obese women

Autor: Emmanuel Disse, Kevin Seyssel, Baptiste Julien, P. Cristini, Maurice Laville, Eric Blond, Stéphanie Lambert-Porcheron, B. Segrestin, Sylvain Iceta
Přispěvatelé: Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre référent pour l’anorexie et les troubles du comportement alimentaire de Lyon (CREATyon), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Hospitalier le Vinatier [Bron], Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Grenoble Alpes (UGA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Europeen Nutrition et Santé, Young Investigator Award of the Hospices Civils de Lyon, France, Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), CRNH Rhône-Alpes, HCL, Mécanique des Matériaux et Procédés (MMP), Laboratoire de Mécanique Gabriel Lamé (LaMé), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Tours-Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Tours, Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Endocrinology
Diabetes and Metabolism
[SDV]Life Sciences [q-bio]
Hospital Anxiety and Depression Scale
0302 clinical medicine
Endocrinology
Risk Factors
Surveys and Questionnaires
stimulates locomotor-activity
2. Zero hunger
Leptin
digestive
oral
and skin physiology
Fasting
General Medicine
Middle Aged
Ghrelin
anorexia-nervosa
3. Good health
Eating disorders
Anxiety
Female
medicine.symptom
dopamine
plasma ghrelin
Adult
medicine.medical_specialty
Vulnerability
030209 endocrinology & metabolism
Drive for thinness
Feeding and Eating Disorders
Young Adult
03 medical and health sciences
Endocrinology & Metabolism
Internal medicine
Internal Medicine
medicine
Humans
Obesity
Disordered eating
gene
business.industry
Feeding Behavior
circulating ghrelin
medicine.disease
Eating Disorder Inventory
Impulsive behaviour
bulimia
business
polymorphisms
Biomarkers
030217 neurology & neurosurgery
Zdroj: Diabetes & metabolism
Diabetes & metabolism, 2019, 45 (2), pp.160--166. ⟨10.1016/j.diabet.2018.01.006⟩
DOI: 10.1016/j.diabet.2018.01.006⟩
Popis: International audience; Aim. - Eating disorders (EDs), disordered eating (DE) and obesity are thought to have overlapping aetiological processes. DE in obesity can jeopardize weight-loss results, and acyl ghrelin (AG) is a hormone that stimulates food intake and reward processes. The main study objective was to determine whether higher-than-expected concentrations of AG in common obesity are associated with DE symptoms. Methods. - The study population included 84 women, aged 20-55 years, free of established EDs: 55 were severely obese (OB) and 29 were of normal weight (NW). OB participants were stratified into two groups according to their median concentration of fasting AG distribution. The OB women with a high fasting plasma ghrelin concentration (HGC) were compared with both OB women with a low fasting plasma ghrelin concentration (LGC) and NW women. Participants were assessed by the Eating Disorder Inventory (EDI-2), Three-Factor Eating Questionnaire (TFEQ) and Hospital Anxiety and Depression Scale (HADS). Fasting glucose, insulin, leptin and ghrelin plasma concentrations were also quantified. Results. - Between the two AG groups of OB women, there was no statistical difference in either anthropometric or metabolic parameters, HADS, TFEQ or fasting hunger scores. However, the HGC group scored significantly higher than the LGC group on the drive-for-thinness subscale of EDI-2 (9.30 +/- 0.99 vs. 6.46 +/- 0.83, respectively; P = 0.033). Conclusion. - Results support the hypothesis of a potential relationship between fasting plasma AG concentrations and ED risk, regardless of mood and anxiety. AG may be considered a potential biomarker of vulnerability for developing EDs. (C) 2018 Elsevier Masson SAS. All rights reserved.
Databáze: OpenAIRE
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