Serum Levels of Lipoxin A4do not Predict the Development of Subsequent Asthma among Young Children with Acute Bronchiolitis
| Autor: | Kong-Sang Wan, Chung-Mei Ni, Winnie Yang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Dinoprostone Body Temperature Leukocyte Count chemistry.chemical_compound White blood cell Internal medicine medicine Humans Immunology and Allergy Child Asthma Sex Characteristics Lipoxin Tumor Necrosis Factor-alpha business.industry Eosinophil Cationic Protein Age Factors Infant Immunoglobulin E Eosinophil medicine.disease Gastroenteritis Lipoxins medicine.anatomical_structure Cytokine chemistry Bronchiolitis Child Preschool Pediatrics Perinatology and Child Health Immunology Female Tumor necrosis factor alpha Interleukin-4 Interleukin-5 business Biomarkers Sex characteristics |
| Zdroj: | Journal of Asthma. 48:576-580 |
| ISSN: | 1532-4303 0277-0903 |
| Popis: | Acute bronchiolitis frequently causes wheezing in infants and young children, although its relationship to asthma remains unclear. We hypothesized that serum lipoxin A(4) levels may be used as an early predictive biomarker of subsequent asthma in young children with acute bronchiolitis.We recruited 69 children who were divided into 3 groups: 47 children younger than 24 months with acute bronchiolitis as an experimental group (Group 1); 11 children aged 2-24 months with viral acute gastroenteritis as a non-allergic control group (Group 2); and 11 children older than 24 months with physician-diagnosed asthma exacerbations as an asthma control group (Group 3). We determined white blood cell counts, eosinophil counts, and serum levels of C-reactive protein, interleukin-4, interleukin-5, prostaglandin E(2), tumor necrosis factor-alpha, and lipoxin A(4).The mean serum levels of lipoxin A(4) in the groups with acute bronchiolitis (1), acute gastroenteritis (2), and asthma (3) were 0.0430.028, 0.0540.015, and 0.0510.031 ng/ml, respectively. When compared by t-tests, there were no significant differences between Groups 1 and 2, or Groups 1 and 3 (p0.05), despite a significant difference between Groups 2 and 3 (p=0.0392). In a final regression model, serum lipoxin A(4) levels were positively correlated with age, female gender, white blood cell counts, and interleukin-5 levels in all patients, while asthma patients had lower serum lipoxin A(4) levels compared to the other two groups.Serum levels of lipoxin A(4) cannot be used as an early predictive diagnostic marker for asthma in young children with acute bronchiolitis. |
| Databáze: | OpenAIRE |
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