Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

Autor: Maria Stefania Lattanzio, Fabrizio Montecucco, Silvia Minetti, Edoardo Elia, Federico Carbone, Emilio Molina-Molina, Daniele Ferrara, Stefania Pugliese, Piero Portincasa, Anna Maria Ansaldo, Anna Belfiore, Vincenzo Palmieri
Jazyk: angličtina
Předmět:
0301 basic medicine
Male
Adipose tissue
030204 cardiovascular system & hematology
Systemic inflammation
0302 clinical medicine
Risk Factors
gender
10. No inequality
Spectroscopy
Metabolic Syndrome
Sex Characteristics
Leptin
General Medicine
Middle Aged
Computer Science Applications
C-Reactive Protein
female
Adipose Tissue
medicine.symptom
Pericardium
medicine.medical_specialty
high-sensitivity c-reactive protein
Adipokine
Inflammation
Intra-Abdominal Fat
leptin
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Internal medicine
medicine
Humans
Obesity
Physical and Theoretical Chemistry
Molecular Biology
Adiponectin
business.industry
visceral fat thickness
Organic Chemistry
medicine.disease
epicardial fat thickness
Sexual dimorphism
030104 developmental biology
Endocrinology
Metabolic syndrome
business
Zdroj: International Journal of Molecular Sciences
Volume 20
Issue 23
ISSN: 1422-0067
DOI: 10.3390/ijms20235981
Popis: Sexual dimorphism accounts for significant differences in adipose tissue mass and distribution. However, how the crosstalk between visceral and ectopic fat depots occurs and which are the determinants of ectopic fat expansion and dysfunction remains unknown. Here, we focused on the impact of gender in the crosstalk between visceral and epicardial fat depots and the role of adipocytokines and high-sensitivity C-reactive protein (hs-CRP). A total of 141 outward patients (both men and women) with one or more defining criteria for metabolic syndrome (MetS) were consecutively enrolled. For all patients, demographic and clinical data were collected and ultrasound assessment of visceral adipose tissue (VFth) and epicardial fat (EFth) thickness was performed. Hs-CRP and adipocytokine levels were assessed by enzyme-linked immunosorbent assay (ELISA). Men were characterized by increased VFth and EFth (p-value <
0.001 and 0.014, respectively), whereas women showed higher levels of adiponectin and leptin (p-value <
0.001 for both). However, only in women VFth and EFth significantly correlated between them (p = 0.013) and also with leptin (p <
0.001 for both) and hs-CRP (p = 0.005 and p = 0.028, respectively). Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (p = 0.012 and 0.007, respectively). In conclusion, men and women present differences in epicardial fat deposition and systemic inflammation. An intriguing association between visceral/epicardial fat depots and chronic low-grade inflammation also emerged. In women Although a further validation in larger studies is needed, these findings suggest a critical role of sex in stratification of obese/dysmetabolic patients.
Databáze: OpenAIRE
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