Pulmonary Tumor Thrombotic Microangiopathy Caused by Urothelial Carcinoma Expressing Vascular Endothelial Growth Factor, Platelet-derived Growth Factor, and Osteopontin
| Autor: | Mai Iwaya, Yasushi Wakabayashi, Akihiro Iijima, Kyohei Yamazaki, Wataru Takeuchi, Mayo Akita |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Platelet-derived growth factor Thrombotic microangiopathy medicine.medical_treatment 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fatal Outcome Internal Medicine Biomarkers Tumor Medicine Humans Osteopontin Aged Platelet-Derived Growth Factor biology business.industry Thrombotic Microangiopathies Growth factor General Medicine medicine.disease Neoplastic Cells Circulating Primary tumor Vascular endothelial growth factor Vascular endothelial growth factor A chemistry Vascular endothelial growth factor C Urinary Bladder Neoplasms 030220 oncology & carcinogenesis biology.protein Cancer research Autopsy business |
| Zdroj: | Internal medicine (Tokyo, Japan). 55(6) |
| ISSN: | 1349-7235 |
| Popis: | Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related pulmonary complication. It is generally caused by gastric adenocarcinoma, and several molecules produced by tumor cells are reported to play important roles in its pathogenesis. We herein report an autopsy case of PTTM caused by urothelial carcinoma. Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and osteopontin were found to be expressed in both the primary tumor cells and metastatic cells in the PTTM lesions. These findings implicate the possible involvement of VEGF, PDGF, and osteopontin in the pathogenesis of PTTM caused by urothelial carcinoma. |
| Databáze: | OpenAIRE |
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