Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation
| Autor: | Javier Rendón Henao, Celeste Sánchez-Romero, Oslei Paes de Almeida, Lady Paola Aristizabal Arboleda, Ricardo Martínez Pedraza, Jesus Alfonso Aguirre Quiñones, Carlos de Jesús Mata Tovar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Pathology medicine.medical_specialty Non-Hodgkin Lymphoma CD3 lcsh:Medicine In situ hybridization Virus Pathology and Forensic Medicine Malaise 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal Medicine medicine Epstein-Barr virus Young adult lcsh:RC31-1245 CD20 biology business.industry lcsh:R Burkitt lymphoma Mouth neoplasms medicine.disease Lymphoma Article / Clinical Case Report 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Immunohistochemistry medicine.symptom business |
| Zdroj: | Autopsy and Case Reports, Vol 9, Iss 4 (2019) Autopsy & Case Reports |
| ISSN: | 2236-1960 |
| Popis: | Sporadic Burkitt lymphoma (SBL) is a variant of Burkitt lymphoma that occurs worldwide, affecting mainly children and young adults. Association with Epstein-Barr virus (EBV) can be identified in approximately 20-30% of cases. Herein we described a case of a 63-year-old male presenting intraoral bilateral mandibular swelling, subjacent to fixed dental prosthesis, with one month of duration. Incisional biopsies were performed, and after two days, the patient was hospitalized due to malaise and breathing difficulty, and died after a week when an abdominal tumor was detected. The mandibular biopsies revealed a diffuse proliferation of medium-sized monomorphic atypical lymphoid cells exhibiting numerous mitoses and areas of “starry-sky” pattern. The tumor showed immunohistochemical positivity for CD20, CD10, Bcl-6, and Ki-67 (≈ 100%); it was negative for CD3, Bcl-2, Vs38c, and MUM-1. Positivity for EBV was found by in situ hybridization. The final diagnosis was intraoral SBL positive for EBV. Clinical, morphological and molecular criteria are necessary for the correct diagnosis of aggressive B-cell neoplasms positive for EBV in elderly patients. |
| Databáze: | OpenAIRE |
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