Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters

Autor: Tomas Petrasek, Klara Tuckova, Kristyna Maleninska, Iveta Vojtechova, Ondrej Klovrza, Viera Kútna, Ales Stuchlik
Rok vydání: 2021
Předmět:
Lipopolysaccharides
Male
sex differences
chronic bacterial infection
parvalbumin-positive interneurons
lcsh:Chemistry
0302 clinical medicine
Pregnancy
lcsh:QH301-705.5
Spectroscopy
Prepulse inhibition
maternal immune activation
Behavior
Animal
biology
lipopolysaccharide
Brain
General Medicine
Immunohistochemistry
Computer Science Applications
Parvalbumins
Maternal Exposure
Schizophrenia
Gestation
Female
Microglia
medicine.medical_specialty
Offspring
autism
macrocephaly
Article
Catalysis
Immunomodulation
Inorganic Chemistry
03 medical and health sciences
Sex Factors
Interneurons
Internal medicine
medicine
Animals
Physical and Theoretical Chemistry
Social Behavior
development
Molecular Biology
business.industry
Organic Chemistry
medicine.disease
Startle reaction
Rats
030227 psychiatry
schizophrenia
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Autism
prenatal infection
business
030217 neurology & neurosurgery
Parvalbumin
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 3274, p 3274 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
ISSN: 1422-0067
DOI: 10.3390/ijms22063274
Popis: Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior of adolescent and adult offspring, as a rat model of these neurodevelopmental disorders. We injected bacterial lipopolysaccharide (LPS, 1 mg/kg) to pregnant Wistar dams from gestational day 7, every other day, up to delivery. Behavior of the offspring was examined in a comprehensive battery of tasks at postnatal days P45 and P90. Several brain parameters were analyzed at P28. The results showed that prenatal immune activation caused social and communication impairments in the adult offspring of both sexes
males were affected already in adolescence. MIA also caused prepulse inhibition deficit in females and increased the startle reaction in males. Anxiety and hypolocomotion were apparent in LPS-affected males and females. In the 28-day-old LPS offspring, we found enlargement of the brain and decreased numbers of parvalbumin-positive interneurons in the frontal cortex in both sexes. To conclude, our data indicate that sex of the offspring plays a crucial role in the development of the MIA-induced behavioral alterations, whereas changes in the brain apparent in young animals are sex-independent.
Databáze: OpenAIRE
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