Effect of in Vivo Pre-Treatment With Oestradiol and Either GnRH, GnRH Agonistic Analog or GnRH Antagonistic Analog on GnRH-stimulated Secretion of LH in Vitro
| Autor: | Hendrik Moes, Tr Koiter, Ga Schuiling |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Agonist
GNRH AGONIST medicine.medical_specialty Pituitary gland endocrine system medicine.drug_class LUTEINIZING-HORMONE Gonadotropin-Releasing Hormone PITUITARY GLAND Cellular and Molecular Neuroscience LH RESPONSE BUSERELIN In vivo PITUITARY-GLAND Internal medicine GNRH BINDING medicine Animals Receptor skin and connective tissue diseases Molecular Biology ESTRADIOL Pharmacology HORMONE-RELEASING HORMONE TERM OVARIECTOMIZED RAT RECEPTOR Chemistry CONTINUOUS INFUSIONS Antagonist Rats Inbred Strains Cell Biology Luteinizing Hormone Buserelin Rats Endocrinology medicine.anatomical_structure Molecular Medicine GNRH ANTAGONIST Luteinizing hormone LRH hormones hormone substitutes and hormone antagonists Endocrine gland medicine.drug |
| Zdroj: | Experientia, 47(7), 716-718 |
| ISSN: | 0014-4754 |
| Popis: | In vivo treatment with GnRH or with GnRH agonistic analog (AG), but not with GnRH antagonistic analog (ANT), depleted the LH stores of the rat pituitary gland. This depletion was potentiated by oestradiol. Oestradiol augmented the in vitro LH response of the pituitary gland to GnRH. This augmenting effect of oestradiol became smaller with increasing rates of in vivo administration of GnRH or AG, but not with ANT. With respect to both depletion of the LH stores and suppression of the augmenting effect of oestradiol, AG ist about 20 times as potent as GnRH. |
| Databáze: | OpenAIRE |
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